主页 / 细胞生物学 / Cell Metabolism / DNA, RNA and Protein Synthesis / DNA, RNA and Protein Synthesis Modulators / RECTAS

RECTAS

Cat. No. 7679 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： IKBKAP pre-mRNA splicing modulator
化学名： 2-Chloro-N-(2-furanylmethyl)-7H-purin-6-amine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for RECTAS

RECTAS (rectifier of aberrant splicing) is a pre-mRNA splicing modulator of the IKBKAP (inhibitor of κ light polypeptide gene enhancer in B-cells, kinase complex associated protein) gene. It corrects aberrant IKBKAP splicing in vitro in cellular models of familial dysautonomia and in vivo in transgenic mice. In combination with Phenylbutyric acid (Cat. No. 2682), RECTAS rescues PARK7 aberrant splicing and neuronal cell loss in a midbrain organoid model of familial Parkinson's disease. Orally bioavailable and brain penetrant.

技术数据 for RECTAS

分子量 249.66
公式 C10H8ClN5O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 101862-47-9
PubChem ID 5037694
InChI Key QGUOPVCOXHVPJX-UHFFFAOYSA-N
Smiles ClC1=NC=2N=CNC2C(=N1)NCC=3OC=CC3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RECTAS

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 24.97 100

制备储备液 for RECTAS

以下数据基于产品分子量 249.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.01 mL 20.03 mL 40.05 mL
5 mM 0.8 mL 4.01 mL 8.01 mL
10 mM 0.4 mL 2 mL 4.01 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for RECTAS

参考文献是支持产品生物活性的出版物。

Ajiro et al (2021) Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia. Nat.Commun. 12 4507 PMID: 34301951

Yoshida et al (2015) Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia. Proc.Natl.Acad.Sci U.S.A. 112 2764 PMID: 25675486

Boussaad et al (2020) A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease. Sci.Transl.Med. 12 eaau3960 PMID: 32908004

If you know of a relevant reference for RECTAS, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 DNA, RNA and Protein Synthesis Modulators

关键词: RECTAS, RECTAS supplier, IKBKAP, splicing, modulator, modulates, familial, dysautonomia, FD, brain, penetrant, orally, bioavailable, PARK7, DJ-1, parkinsons, disease, DNA,, RNA, and, Protein, Synthesis, Polymerase, 7679, Tocris Bioscience

篇 RECTAS 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 RECTAS 的引用文献。 您是否知道使用了 Tocris RECTAS 的优秀论文？ 请告知我们.

RECTAS 的评论

目前没有该产品的评论。 Be the first to review RECTAS and earn rewards!

Have you used RECTAS?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Huntington's Disease Research Product Guide

Huntington's Disease Research Product Guide

This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:

  • Somatic Instability
  • Proteolysis and Inclusion Bodies
  • Transcriptional Dysregulation
  • Mitochondrial Dysfunction
  • Nuclear-Cytoplasmic Transport Interference
  • Excitotoxicity
  • Stem Cells