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Repaglinide

Cat. No. 3805 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Kir6 (KATP) channel blocker
别名： AG-EE 623ZW
化学名： 2-Ethoxy-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]benzoic acid
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Repaglinide

Repaglinide is a Kir6 (KATP) channel blocker that binds with high affinity for SUR1 when co-expressed with Kir6.2 (Kd = 0.42 nM). Antidiabetic glucose regulator with hypoglycaemic effect in vivo.

化合物库 for Repaglinide

Repaglinide is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Repaglinide

分子量 452.59
公式 C27H36N2O4
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 135062-02-1
PubChem ID 65981
InChI Key FAEKWTJYAYMJKF-QHCPKHFHSA-N
Smiles O=C(CC3=CC(OCC)=C(C(O)=O)C=C3)N[C@@H](CC(C)C)C1=CC=CC=C1N2CCCCC2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Repaglinide

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 45.26 100
ethanol 45.26 100

制备储备液 for Repaglinide

以下数据基于产品分子量 452.59。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.05 mL 22.1 mL
5 mM 0.44 mL 2.21 mL 4.42 mL
10 mM 0.22 mL 1.1 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for Repaglinide

参考文献是支持产品生物活性的出版物。

Mark and Grell (1997) Hypoglycaemic effects of the novel antidiabetic agent repagl. in rats and dogs. Br.J.Pharmacol. 121 1597 PMID: 9283692

Hansen et al (2005) Kir6.2-dependent high-affinity repagl. binding to β-cell KATP channels. Br.J.Pharmacol. 144 551 PMID: 15678092

If you know of a relevant reference for Repaglinide, please let us know.

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关键词: Repaglinide, Repaglinide supplier, K+, channel, pore, blockers, KATP, Blocks, SUR1, KIR6, Kir6.2, sulphonylurea, receptor, inward, rectifier, AG-EE, 623ZW, Inward, Potassium, Channels, 3805, Tocris Bioscience

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