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Submit ReviewResveratrol
说明： Cyclooxygenase inhibitor
化学名： 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3,benzenediol
纯度： ≥98% (HPLC)
生物活性 for Resveratrol
Resveratrol is a phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects. Inhibits cytochrome P450 1A1 (IC50 = 23 μM) and displays mixed agonist/antagonist actions at ERα and ERβ estrogen receptors. Converted into the anticancer agent piceatannol (Cat. No. 1554) by cytochrome P450 1B1. Activates autophagy. Also activates TRPA1 in prostate cancer-associated fibroblasts. Also SIRT1 activator.
化合物库 for Resveratrol
Resveratrol is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。
技术数据 for Resveratrol
| 分子量 | 228.25 |
| 公式 | C14H12O3 |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 501-36-0 |
| PubChem ID | 445154 |
| InChI Key | LUKBXSAWLPMMSZ-OWOJBTEDSA-N |
| Smiles | OC1=CC=C(C=C1)\C=C\C1=CC(O)=CC(O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Resveratrol
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 100 | ||
| DMSO | 22.82 | 100 |
制备储备液 for Resveratrol
以下数据基于产品分子量 228.25。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.38 mL | 21.91 mL | 43.81 mL |
| 5 mM | 0.88 mL | 4.38 mL | 8.76 mL |
| 10 mM | 0.44 mL | 2.19 mL | 4.38 mL |
| 50 mM | 0.09 mL | 0.44 mL | 0.88 mL |
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产品说明书 for Resveratrol
参考文献 for Resveratrol
参考文献是支持产品生物活性的出版物。
Baur and Sinclair (2006) Therapeutic potential of resveratrol: the in vivo evidence. Nat.Rev.Drug Discov. 5 493 PMID: 16732220
Bowers et al (2000) Resveratrol acts as a mixed agonist/antagonist for estrogen receptors α and β. Endocrinology 141 3657 PMID: 11014220
Chun et al (1999) Resveratrol is a selective human cytochrome P450 1A1 inhibitor. Biochem.Biophys.Res.Commun. 262 20 PMID: 10448061
Fremont (2000) Biological effects of resveratrol. Life Sci. 66 663 PMID: 10680575
Kimura et al (1985) Effects of stilbenes on arachidonate metabolism in leukocytes. Biochim.Biophys.Acta 834 275 PMID: 3922423
Baptista et al (2013) Regulation of histone H2A.Z exprsesion is mediated by sirtuin 1 in prostate cancer. Oncotarget 4 1673 PMID: 24127549
Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316
Vancauwenberghe et al (2017) Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF). Mol.Carcinog. 56 1851 PMID: 28277613
If you know of a relevant reference for Resveratrol, please let us know.
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关键词: Resveratrol, Resveratrol supplier, Antitumor, anti-oxidant, agent, Cyclooxygenase, inhibitors, inhibits, COX, Oxygenases, Oxidases, Antiangiogenics, Antioxidants, Class, III, HDACs, (Sirtuins), Autophagy, TRPA1, 1418, Tocris Bioscience
7 篇 Resveratrol 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Resveratrol 的部分引用包括：
Chen et al (2014) A critical role for IF. regulatory factor 9 in cerebral ischemic stroke. J Neurosci 34 11897 PMID: 25186738
Rojas et al (2014) Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress. Front Cell Neurosci 8 24 PMID: 24570655
Jiang and Zsombok (2014) Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1. Front Neurosci 7 270 PMID: 24454277
Wang et al (2013) Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. Cancer Res 2013 857929 PMID: 23762164
Meftahi et al (2015) Suppressive Effects of Resveratrol Treatment on The Intrinsic Evoked Excitability of CA1 Pyramidal Neurons. Evid Based Complement Alternat Med 17 532 PMID: 26464825
Pacholec et al (2010) SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem 285 8340 PMID: 20061378
Ohshiro et al (2007) Identifying the estrogen receptor coactivator PELP1 in autophagosomes. Br J Pharmacol 67 8164 PMID: 17804729
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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