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RG 108

Cat. No. 3295 3 篇引用文献 2 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Non-nucleoside DNA methyltransferase inhibitor
化学名： N-Phthalyl-L-tryptophan
纯度： ≥99% (HPLC)
说明书
引用文献 (3)
评论 (2)
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for RG 108

RG 108 is a non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes. Enhances the efficiency of induced pluripotent stem cell (iPS) generation.

化合物库 for RG 108

RG 108 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for RG 108

分子量 334.33
公式 C19H14N2O4
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 48208-26-0
PubChem ID 702558
InChI Key HPTXLHAHLXOAKV-INIZCTEOSA-N
Smiles O=C(C(C=CC=C4)=C4C3=O)N3[C@H](C(O)=O)CC2=CNC1=CC=CC=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RG 108

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 33.43 100
ethanol 33.43 100

制备储备液 for RG 108

以下数据基于产品分子量 334.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.99 mL 14.96 mL 29.91 mL
5 mM 0.6 mL 2.99 mL 5.98 mL
10 mM 0.3 mL 1.5 mL 2.99 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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产品说明书 for RG 108

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for RG 108

参考文献是支持产品生物活性的出版物。

Brueckner et al (2005) Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of DNA methyltransferase. Cancer Res. 65 6305 PMID: 16024632

Stresemann et al (2006) Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res. 66 2794 PMID: 16510601

Schirrmacher et al (2006) Synthesis and in vitro evaluation of biotinylated RG108: a high affinity compound for studying binding interactions with human DNA methyltransferases. Bioconjug.Chem. 17 261 PMID: 16536454

If you know of a relevant reference for RG 108, please let us know.

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关键词: RG 108, RG 108 supplier, Non-nucleoside, DNA, methyltransferase, inhibitor, inhibitors, transferases, RG108, inhibits, methylation, dnmt, epigenetics, Methyltransferases, Stem, Cell, Reprogramming, 3295, Tocris Bioscience

3 篇 RG 108 的引用文献

引用文献是使用了 Tocris 产品的出版物。 RG 108 的部分引用包括：

Kottakis et al (2016) LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Nature 539 390 PMID: 27799657

Nugent et al (2015) Brain feminization requires active repression of masculinization via DNA methylation. PLoS One 18 690 PMID: 25821913

Zhang et al (2016) Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell 18 653 PMID: 27133794

您是否知道使用了 Tocris RG 108 的优秀论文？ 请告知我们.

RG 108 的评论

平均评分: 5 (基于 2 条评论。)

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Highly stable.
By Anonymous on 06/25/2020
分析类型： In Vitro
种属： Mouse
细胞系/组织： Neural Stem Cells

Cells are treated with 10 µM RG 108

PMID: 27133794
review image
We got expected effect on cells.
By Anonymous on 04/03/2020
分析类型： In Vitro
种属： Mouse
细胞系/组织： Primary pancreatic ductal epithelial cells

100 μM RG108

review image

该领域的文献

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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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Epigenetics Scientific Review

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