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Submit ReviewRGD peptide
说明： Minimal recognition sequence for integrin binding; potent integrin inhibitor
纯度： ≥95% (HPLC)
生物活性 for RGD peptide
RGD peptide is a potent integrin inhibitor (IC50 values are 89, 335 and 440 nM for αvβ3, α5β1 and αvβ5, respectively). RGD is the minimal recognition sequence for integrin binding found in many extracellular matrix (ECM) and serum proteins. RGD peptide is used for directing association of various cell types with diverse biomaterials. The functionality of RGD peptide is usually maintained throughout the processing and sterilization steps required for biomaterials synthesis. RGD peptide can be incorporated into hyaluronic acid hydrogel for human mesenchymal stem cells (hMSCs) delivery. RGD peptide significantly increases hMSC spreading and protein secretion under standard or ischemic culture conditions. RGD peptide can also be incorporated into alginate bioink for 3D bioprinting of MSCs onto cartilage templates for bone organogenesis.
技术数据 for RGD peptide
| 分子量 | 346.34 |
| 公式 | C12H22N6O6 |
| 序列 | RGD |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 99896-85-2 |
| PubChem ID | 104802 |
| InChI Key | IYMAXBFPHPZYIK-BQBZGAKWSA-N |
| Smiles | O=C(NCC(N[C@@H](CC(O)=O)C(O)=O)=O)[C@H](CCCNC(N)=N)N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for RGD peptide
| 溶解性 | Soluble to 10 mg/ml in water |
产品说明书 for RGD peptide
参考文献 for RGD peptide
参考文献是支持产品生物活性的出版物。
Bellis (2011) Advantages of RGD peptides for directing cell association with biomaterials. Biomaterials 32 4205 PMID: 21515168
Ruoslahti et al (1987) New perspectives in cell adhesion: RGD and integrins. Science 238 491 PMID: 2821619
Kapp et al (2017) A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins. Sci.Rep. 7 39805 PMID: 28074920
Gallagher et al (2020) Pre-culture of mesenchymal stem cells within RGD-modified hyaluronic acid hydrogel improves their resilience to ischaemic conditions. Acta.Biomater. 107 78 PMID: 32145393
Daly et al (2016) 3D bioprinting of developmentally inspired templates for whole bone organ engineering. Adv.Healthc.Mater. 5 2353 PMID: 27281607
If you know of a relevant reference for RGD peptide, please let us know.
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