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RI 1

Cat. No. 6168 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6168 has been discontinued.

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说明： RAD51 recombinase inhibitor
化学名： 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for RI 1

RI 1 is a RAD51 inhibitor (IC50 is in the range 5 - 30 μM). Covently binds C139 on protein surface. Inhibits homologous recombination. Cell permeable. Sensitizes tumor cells to chemotherapy.

技术数据 for RI 1

分子量 361.61
公式 C14H11Cl3N2O3
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 415713-60-9
PubChem ID 1074953
InChI Key MWSUIZKGNWELRF-UHFFFAOYSA-N
Smiles ClC1=C(C(N(C2=CC(Cl)=C(C=C2)Cl)C1=O)=O)N3CCOCC3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for RI 1

参考文献是支持产品生物活性的出版物。

Budke et al (2012) RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res. 40 7347 PMID: 22573178

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关键词: RI 1, RI 1 supplier, RI1, RAD51, recombinase, inhibitors, inhibits, HR, homologous, repair, chemosensitizers, chemosensitisers, DNA,, RNA, and, Protein, Synthesis, 6168, Tocris Bioscience

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