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Submit ReviewRifaximin
说明： Pregnane X receptor agonist; antibiotic
化学名： (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione
纯度： ≥98% (HPLC)
生物活性 for Rifaximin
Rifaximin is a pregnane X receptor (PXR) agonist; antibiotic. Reduces number of colon tumors and suppresses expression of TNFα and Il-1β induced in a colon cancer, PXR-humanized mouse model. Increases apoptosis and decreased proliferation in HT-29 cells. Exhibits low gastrointestinal absorption while retaining its antibacterial activity. Active against gram-positive and gram-negative bacteria.
化合物库 for Rifaximin
Rifaximin is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Rifaximin
| 分子量 | 785.88 |
| 公式 | C43H51N3O11 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 80621-81-4 |
| PubChem ID | 6436173 |
| InChI Key | NZCRJKRKKOLAOJ-XRCRFVBUSA-N |
| Smiles | O=C(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@H]([C@H]([C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)/C=C/O[C@@]5(C)O4)O)C)NC2=C(O)C1=C(O)C(C)=C4C(C5=O)=C1C3=C2N6C(C=C(C)C=C6)=N3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Rifaximin
参考文献 for Rifaximin
参考文献是支持产品生物活性的出版物。
Cheng et al (2014) Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer. J.Pharmacol.Exp.Ther. 351 559 PMID: 25277138
Jiang et al (2005) Rifaximin: in vitro and in vivo antibacterial activity-a review. Chemotherapy 51 67 PMID: 15855749
Stradi et al (2010) Structural elucidation of the rifa. Ph. Eur. Impurity H. J.Pharm.Biomed.Anal. 51 858 PMID: 19926422
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关键词: Rifaximin, Rifaximin supplier, Antibiotic, Pregnane, X, receptors, agonists, PXR, colon, tumors, tumours, gram, positive, negative, bacteria, Receptor, Antibiotics, Apoptosis, Inducers, 5359, Tocris Bioscience
Rifaximin 的评论
平均评分: 4 (Based on 1 Review.)
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Rifaximin used in resistance study against E.Coli.
By
Anonymous on 02/11/2019
种属： Human
Rifaximin was used against E.coli in comparison with Rifampine. Resistance study of E.coli was being carried out.
该领域的文献
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Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.