Ritonavir

Cat. No. 5856 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： HIV-1 and HIV-2 protease inhibitor

别名： ABT-538,A-84538,Abbot 84538

化学名： 5-Thiazolylmethyl (3S,4S,6S,9S)-4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoate

纯度： ≥98% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Ritonavir

Ritonavir is a HIV-1 and HIV-2 protease inhibitor (EC₅₀ values are 0.022-0.13 and 0.16 μM, respectively). Blocks the metabolism of protease inhibitors by liver enzyme cytochrome P450-3A4 (CYP3A4). Orally bioavailable. When used in combination with lopinavir, improves outcome in an animal model of MERS-CoV infection.

化合物库 for Ritonavir

Ritonavir is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Ritonavir

分子量	720.94
公式	C₃₇H₄₈N₆O₅S₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	155213-67-5
PubChem ID	392622
InChI Key	NCDNCNXCDXHOMX-XGKFQTDJSA-N
Smiles	O[C@@H](C[C@@H](NC([C@H](C(C)C)NC(N(C)CC1=CSC(C(C)C)=N1)=O)=O)CC2=CC=CC=C2)[C@@H](NC(OCC3=CN=CS3)=O)CC4=CC=CC=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ritonavir

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	14.42	20 温和加热
	ethanol	7.21	10

制备储备液 for Ritonavir

以下数据基于产品分子量 720.94。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	6.94 mL	34.68 mL	69.35 mL
1 mM	1.39 mL	6.94 mL	13.87 mL
2 mM	0.69 mL	3.47 mL	6.94 mL
10 mM	0.14 mL	0.69 mL	1.39 mL

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产品说明书 for Ritonavir

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Ritonavir

参考文献是支持产品生物活性的出版物。

Kempf et al (1995) ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans. Proc.Natl.Acad.Sci.U.S.A. 92 2484 PMID: 7708670

Kempf et al (1998) Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy. J.Med.Chem. 41 602 PMID: 9484509

Zeldin et al (2004) Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIV-infected patients. J.Antimicrob.Chemother. 53 4 PMID: 14657084

Chan et al (2015) Treatment with Lopinavir/Ritonavir or Interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset. J.Infect.Dis. 12 1904 PMID: 26198719

If you know of a relevant reference for Ritonavir, please let us know.

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关键词: Ritonavir, Ritonavir supplier, HIV-1, HIV-2, proteases, inhibitors, inhibits, cytochrome, P450-3A4, human, immunodeficiency, virus, orally, active, MERS-CoV, middle, east, respiratory, syndrome, coronaviruses, ABT-538, A-84538, Abbot, 84538, COVID-19, HIV, Protease, Coronavirus, 5856, Tocris Bioscience

1 篇 Ritonavir 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Ritonavir 的部分引用包括：

Matthew B et al (2021) The HIV protease inhibitor, ritonavir, corrects diverse brain phenotypes across development in mouse model of DYT-TOR1A dystonia. Sci Transl Med 13 PMID: 34408078

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