RN 1 dihydrochloride

Cat. No. 4977 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： LSD1 inhibitor

化学名： 1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanone dihydrochloride

纯度： ≥97% (HPLC)

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for RN 1 dihydrochloride

RN 1 dihydrochloride is a potent lysine specific demethylase 1 (LSD1) inhibitor (IC₅₀ = 70 nM). Exhibits selectivity for LSD1 over MAO-A and MAO-B (IC₅₀ values are 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). Impairs long-term, but not short-term memory in mice. Brain penetrant following systemic administration.

化合物库 for RN 1 dihydrochloride

RN 1 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for RN 1 dihydrochloride

分子量	452.42
公式	C₂₃H₂₉N₃O₂.2HCl
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	1781835-13-9
PubChem ID	90488995
InChI Key	WMHAFZOOUBPQRX-VSIGASKDSA-N
Smiles	O=C(N4CCN(C)CC4)CN[C@@H]1C[C@H]1[C@]2=CC=C(OCC3=CC=CC=C3)C=C2.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RN 1 dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	9.05	20
	DMSO	9.05	20 温和加热

制备储备液 for RN 1 dihydrochloride

以下数据基于产品分子量 452.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	11.05 mL	55.26 mL	110.52 mL
1 mM	2.21 mL	11.05 mL	22.1 mL
2 mM	1.11 mL	5.53 mL	11.05 mL
10 mM	0.22 mL	1.11 mL	2.21 mL

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产品说明书 for RN 1 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for RN 1 dihydrochloride

参考文献是支持产品生物活性的出版物。

Neelamegam et al (2012) Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem.Neurosci. 3 120 PMID: 22754608

If you know of a relevant reference for RN 1 dihydrochloride, please let us know.

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关键词: RN 1 dihydrochloride, RN 1 dihydrochloride supplier, RN1, dihydrochloride, LSD1, lysine-specific, demethylase, 1, histone, demethylases, monoamine, oxidases, MAOs, inhibitors, inhibits, selective, Histone, Demethylases, 4977, Tocris Bioscience

1 篇 RN 1 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 RN 1 dihydrochloride 的部分引用包括：

Llewellyn et al (2018) HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency. J Neurovirol 24 192 PMID: 29256041

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.