Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewRo 5-3335
说明： Core binding factor inhibitor; attenuates hematopoiesis
别名： CBFβ-Runx1 inhibitor II
化学名： 7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one
纯度： ≥98% (HPLC)
生物活性 for Ro 5-3335
Ro 5-3335 is a core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Reduces leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. Also a Tat antagonist; inhibits HIV-1 replication in vitro.
化合物库 for Ro 5-3335
Ro 5-3335 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for Ro 5-3335
| 分子量 | 259.69 |
| 公式 | C13H10ClN3O |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 30195-30-3 |
| PubChem ID | 64983 |
| InChI Key | XWNMORIHKRROGW-UHFFFAOYSA-N |
| Smiles | O=C1CN=C(C3=CC=CN3)C2=C(C=CC(Cl)=C2)N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Ro 5-3335
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 25.96 | 100 |
制备储备液 for Ro 5-3335
以下数据基于产品分子量 259.69。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.85 mL | 19.25 mL | 38.51 mL |
| 5 mM | 0.77 mL | 3.85 mL | 7.7 mL |
| 10 mM | 0.39 mL | 1.93 mL | 3.85 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.77 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for Ro 5-3335
参考文献 for Ro 5-3335
参考文献是支持产品生物活性的出版物。
Cunningham et al (2012) Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBF beta interaction. Proc.Natl.Acad.Sci.USA 109 14592 PMID: 22912405
Cupelli et al (1995) The human immunodeficiency virus type 1 Tat antagonist, Ro 5-3335, predominantly inhibits transcription initiation from the viral promoter. J.Virol. 69 2640 PMID: 7884917
Okuda et al (2001) RUNX1/AML1: a central player in hematopoiesis. Int. J. Hematol. 74 252 PMID: 11721959
If you know of a relevant reference for Ro 5-3335, please let us know.
按产品操作查看相关产品
关键词: Ro 5-3335, Ro 5-3335 supplier, Ro5-3335, CBF, core, binding, factor, Leukemia, inhibitors, inhibits, runt-related, transcription, 1, RUNX1, acute, myeloid, leukemia, protein, AML1, CBFβ, CBFα, hematopoiesis, HIV-1, replication, antiviral, CBFβ-Runx1, II, CBFbeta-Runx1, inhibitor, Other, Transcription, Factors, 4694, Tocris Bioscience
2 篇 Ro 5-3335 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Ro 5-3335 的部分引用包括：
Luo et al (2016) Runt-related Transcription Factor 1 (RUNX1) Binds to p50 in Macrophages and Enhances TLR4-triggeredInflammation and Septic Shock. Journal of Biological Chemistry PMID: 27573239
Jean Y et al (2022) LY6D marks pre-existing resistant basosquamous tumor subpopulations. Nat Commun 13 7520 PMID: 36473848
您是否知道使用了 Tocris Ro 5-3335 的优秀论文？ 请告知我们.
Ro 5-3335 的评论
目前没有该产品的评论。 Be the first to review Ro 5-3335 and earn rewards!
Have you used Ro 5-3335?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image