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Rotenone

Cat. No. 3616 14 篇引用文献 2 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibits complex I of the mitochondrial electron transport chain
化学名： (2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one
纯度： ≥95% (HPLC)
说明书
引用文献 (14)
评论 (2)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Rotenone

Rotenone is a mitochondrial electron transport chain inhibitor (IC50 = 1.7 - 2.2 μM at complex I). Inhibits NADH oxidation by cardiac sarcoplasmic reticulum (IC50 = 3.4 nM). Commonly used pesticide and induces Parkinsonism in animal models. May also inhibit autophagy induction; blocks lysosomal degradation of autophagic vacuoles. Cell-permeable and brain penetrant.

技术数据 for Rotenone

分子量 394.42
公式 C23H22O6
储存 Store at RT
纯度 ≥95% (HPLC)
CAS Number 83-79-4
PubChem ID 6758
InChI Key JUVIOZPCNVVQFO-HBGVWJBISA-N
Smiles C=[C@](C)[C@@H](C5)OC4=C5C(O3)=C(C=C4)C([C@@]([C@@]3([H])CO2)([H])C1=C2C=C(OC)C(OC)=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Rotenone

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.44 100

制备储备液 for Rotenone

以下数据基于产品分子量 394.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.54 mL 12.68 mL 25.35 mL
5 mM 0.51 mL 2.54 mL 5.07 mL
10 mM 0.25 mL 1.27 mL 2.54 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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产品说明书 for Rotenone

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Rotenone

参考文献是支持产品生物活性的出版物。

Cherednichenko et al (2004) NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release. Circ.Res. 94 478 PMID: 14699012

Uversky (2004) Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration. Cell Tissue Res. 318 225 PMID: 15258850

Gomez et al (2007) Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome. Front.Biosci. 12 1079 PMID: 17127363

Mader et al (2012) Rotenone inhibits autophagic flux prior to inducing cell death. ACS Chem.Neurosci. 3 1063 PMID: 23259041

If you know of a relevant reference for Rotenone, please let us know.

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关键词: Rotenone, Rotenone supplier, inhibitors, inhibits, complex, I, mitochondrial, electron, transport, chain, Oxidative, phosphorylation, parkinson's, parkinsons, parkinsonism, Phosphorylation, 3616, Tocris Bioscience

14 篇 Rotenone 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Rotenone 的部分引用包括：

Agarwal et al (2017) Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron 93 587 PMID: 28132831

Battefeld et al (2019) High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling. Cell Rep 26 182 PMID: 30605675

Martin et al (2017) A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Cell Rep 20 427 PMID: 28700943

Moloney et al (2017) Subcellular localization of the FLT3-ITD oncogene plays a significant role in the production of NOX- and p22(phox)-derived reactive oxygen species in acute myeloid leukemia. Leuk Res 52 34 PMID: 27870947

Shai et al (2016) Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response. Nature 533 416-9 PMID: 27135930

Kurt I et al (2021) Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms. Cell Rep 34 108750 PMID: 33596424

Heng et al (2022) SOX2 mediates metabolic reprogramming of prostate cancer cells. Oncogene 41 1190-1202 PMID: 35067686

Banh et al (2016) PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia. Nat Cell Biol 18 803 PMID: 27323329

Toby et al (2020) The influence of hypoxia and energy depletion on the response of endothelial cells to the vascular disrupting agent combretastatin A-4-phosphate. Sci Rep 10 9926 PMID: 32555222

Luke et al (2020) Automated Quantification of Mitochondrial Fragmentation in an In Vitro Parkinson's Disease Model. Curr Protoc Neurosci 94 e105 PMID: 33147381

Hui et al (2019) Loss of PINK1 causes age-dependent decrease of dopamine release and mitochondrial dysfunction. Neurobiol Aging 75 1-10 PMID: 30504091

Beyer et al (2014) An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles. Am J Physiol Heart Circ Physiol 307 H1587 PMID: 25260615

Juliana et al (2012) Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. Leukemia 287 36617 PMID: 22948162

Sandra L et al (2023) Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix. iScience 26 105965 PMID: 36824274

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Rotenone 的评论

平均评分: 4.5 (基于 2 条评论。)

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Strong inhibitor of the mitochondrial complex I..
By Anonymous on 11/12/2021
分析类型： In Vitro
种属： Rat
细胞系/组织： motor neurons

Effect of rotenone (10 micromolar) on AMPA induced ROS formation in motor neurons.

review image
Good choice!.
By Anton Mukhamedshin on 02/22/2019
分析类型： Ex Vivo
种属： Human
细胞系/组织： Platelets

I use it to inhibit mitochondrial electron transport chain in platelets. It helps to understand the role of mitochondria in thrombosis.

Nice delivery time and all works well!

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