RP 001 hydrochloride

Cat. No. 4289 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent S1P₁ agonist

化学名： N-[4-[5-[3-Cyano-4-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]-β-alanine hydrochloride

纯度： ≥98% (HPLC)

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for RP 001 hydrochloride

RP 001 hydrochloride is a potent agonist of S1P₁ receptors (EC₅₀ = 9 pM). Induces internalization and polyubiquitination of S1P₁ in vitro. Selective for S1P₁ over S1P₂ - S1P₄.

化合物库 for RP 001 hydrochloride

RP 001 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for RP 001 hydrochloride

分子量	468.93
公式	C₂₄H₂₄N₄O₄.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1781880-34-9
PubChem ID	90488927
InChI Key	ZHPGSGYEFGEZAL-UHFFFAOYSA-N
Smiles	CC(C)OC1=C(C#N)C=C(C2=NC(C3=C(CCC4NCCC(O)=O)C4=CC=C3)=NO2)C=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RP 001 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	43.25	100

制备储备液 for RP 001 hydrochloride

以下数据基于产品分子量 468.93。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.13 mL	10.66 mL	21.33 mL
5 mM	0.43 mL	2.13 mL	4.27 mL
10 mM	0.21 mL	1.07 mL	2.13 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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产品说明书 for RP 001 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for RP 001 hydrochloride

参考文献是支持产品生物活性的出版物。

Cahalan et al (2011) Actions of a picomolar short-acting S1P₁ agonist in S1P₁-eGFP knock-in mice. Nat.Chem.Biol. 7 254 PMID: 21445057

If you know of a relevant reference for RP 001 hydrochloride, please let us know.

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Sphingosine-1-Phosphate Receptors

关键词: RP 001 hydrochloride, RP 001 hydrochloride supplier, RP001, sphingosine, 1, phosphate, s1p1, receptors, agonists, selective, Sphingosine-1-phosphate, Receptors, 4289, Tocris Bioscience

2 篇 RP 001 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 RP 001 hydrochloride 的部分引用包括：

Li et al (2019) RP001 hydrochloride improves neurological outcome after subarachnoid hemorrhage. J.Neurol.Sci. 399 6 PMID: 30738334

Masato et al (2018) Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production. Cell 174 636-648.e18 PMID: 30017246

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