Rucaparib camsylate

Cat. No. 6230 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： PARP inhibitor

别名： CO-338

化学名： 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2,ef][2]benzazepin-6-one (1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid

纯度： ≥98% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Rucaparib camsylate

Rucaparib camsylate is a PARP inhibitor. Chemosensitizes colorectal cancer cells to Temozolomide (Cat. No. 2706) and Topotecan (Cat. No. 4562) in vitro and in vivo.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for Rucaparib camsylate

Rucaparib camsylate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Rucaparib camsylate

分子量	555.66
公式	C₁₉H₁₈FN₃O.C₁₀H₁₆O₄S
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1859053-21-6
PubChem ID	53356947
InChI Key	INBJJAFXHQQSRW-FHIDHQGESA-N
Smiles	CNCC1=CC=C(C2=C3CCNC(C4=C3C(N2)=CC(F)=C4)=O)C=C1.O=S(C[C@@]5(C6(C)C)CC[C@@H]6CC5=O)(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Rucaparib camsylate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	55.57	100

制备储备液 for Rucaparib camsylate

以下数据基于产品分子量 555.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.8 mL	9 mL	18 mL
5 mM	0.36 mL	1.8 mL	3.6 mL
10 mM	0.18 mL	0.9 mL	1.8 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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产品说明书 for Rucaparib camsylate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Rucaparib camsylate

参考文献是支持产品生物活性的出版物。

Thomas et al (2007) Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial. Mol.Cancer Ther. 6 945 PMID: 17363489

If you know of a relevant reference for Rucaparib camsylate, please let us know.

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关键词: Rucaparib camsylate, Rucaparib camsylate supplier, PARP, inhibitors, inhibits, Poly(ADP-ribose), Polymerase, chemosentizers, chemosensitizes, CO-338, 6230, Tocris Bioscience

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