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Submit Review(S)-(-)-Blebbistatin is a selective inhibitor of myosin II ATPase activity (IC50 ~0.5 - 5 μM); active enantiomer of (±)-blebbistatin. Inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. (S)-(-)-Blebbistatin rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.
Inactive Enantiomer and Racemate also available.
分子量 | 292.34 |
公式 | C18H16N2O2 |
储存 | Store at +4°C |
纯度 | ≥99% (HPLC) |
CAS Number | 856925-71-8 |
PubChem ID | 5287792 |
InChI Key | LZAXPYOBKSJSEX-GOSISDBHSA-N |
Smiles | O=C2[C@@]3(O)C(N(C4=CC=CC=C4)CC3)=NC1=CC=C(C)C=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 29.23 | 100 |
以下数据基于产品分子量 292.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 3.42 mL | 17.1 mL | 34.21 mL |
5 mM | 0.68 mL | 3.42 mL | 6.84 mL |
10 mM | 0.34 mL | 1.71 mL | 3.42 mL |
50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
参考文献是支持产品生物活性的出版物。
Limouze et al (2004) Specificity of blebbistatin, an inhibitor of myosin II. J.Muscle Res.Cell Motil. 25 337 PMID: 15548862
Straight et al (2003) Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor. Science 299 1743 PMID: 12637748
Straight et al (2002) Dissecting cytokinesis with small molecules. Amer.Soc.Cell Biol.Abstr. 2515
If you know of a relevant reference for (S)-(-)-Blebbistatin, please let us know.
关键词: (S)-(-)-Blebbistatin, (S)-(-)-Blebbistatin supplier, Selective, inhibitors, inhibits, myosin, II, ATPase, Myosin, 1852, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 (S)-(-)-Blebbistatin 的部分引用包括:
Schiff et al (2019) P38 inhibition reverses TGFβ1 and TNFα-induced contraction in a model of proliferative vitreoretinopathy. Commun Biol 2 162 PMID: 31069271
Bzymek et al (2016) Real-time two- and three-dimensional imaging of monocyte motility and navigation on planar surfaces and in collagen matrices: roles of Rho. Sci Rep 6 25016 PMID: 27122054
Maître et al (2016) Asymmetric division of contractile domains couples cell positioning and fate specification. Nature 536 344 PMID: 27487217
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