(S)-(-)-Blebbistatin

Cat. No. 1852 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective inhibitor of myosin II ATPase activity. Active enantiomer of (±)-blebbistatin (Cat. No. 1760)

化学名： (3aS)-(-)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one

纯度： ≥99% (HPLC)

引用文献 (3)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for (S)-(-)-Blebbistatin

(S)-(-)-Blebbistatin is a selective inhibitor of myosin II ATPase activity (IC₅₀ ~0.5 - 5 μM); active enantiomer of (±)-blebbistatin. Inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. (S)-(-)-Blebbistatin rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.

Inactive Enantiomer and Racemate also available.

技术数据 for (S)-(-)-Blebbistatin

分子量	292.34
公式	C₁₈H₁₆N₂O₂
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	856925-71-8
PubChem ID	5287792
InChI Key	LZAXPYOBKSJSEX-GOSISDBHSA-N
Smiles	O=C2[C@@]3(O)C(N(C4=CC=CC=C4)CC3)=NC1=CC=C(C)C=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (S)-(-)-Blebbistatin

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	29.23	100

制备储备液 for (S)-(-)-Blebbistatin

以下数据基于产品分子量 292.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.42 mL	17.1 mL	34.21 mL
5 mM	0.68 mL	3.42 mL	6.84 mL
10 mM	0.34 mL	1.71 mL	3.42 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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产品说明书 for (S)-(-)-Blebbistatin

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (S)-(-)-Blebbistatin

参考文献是支持产品生物活性的出版物。

Limouze et al (2004) Specificity of blebbistatin, an inhibitor of myosin II. J.Muscle Res.Cell Motil. 25 337 PMID: 15548862

Straight et al (2003) Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor. Science 299 1743 PMID: 12637748

Straight et al (2002) Dissecting cytokinesis with small molecules. Amer.Soc.Cell Biol.Abstr. 2515

If you know of a relevant reference for (S)-(-)-Blebbistatin, please let us know.

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关键词: (S)-(-)-Blebbistatin, (S)-(-)-Blebbistatin supplier, Selective, inhibitors, inhibits, myosin, II, ATPase, Myosin, 1852, Tocris Bioscience

3 篇 (S)-(-)-Blebbistatin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (S)-(-)-Blebbistatin 的部分引用包括：

Bzymek et al (2016) Real-time two- and three-dimensional imaging of monocyte motility and navigation on planar surfaces and in collagen matrices: roles of Rho. Sci Rep 6 25016 PMID: 27122054

Maître et al (2016) Asymmetric division of contractile domains couples cell positioning and fate specification. Nature 536 344 PMID: 27487217

Schiff et al (2019) P38 inhibition reverses TGFβ1 and TNFα-induced contraction in a model of proliferative vitreoretinopathy. Commun Biol 2 162 PMID: 31069271

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