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Submit Review(R)-(+)-Blebbistatin
Description: Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (±)-blebbistatin (Cat. No. 1760)
Chemical Name: (3aR)-(+)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
Purity: ≥99% (HPLC)
Biological Activity for (R)-(+)-Blebbistatin
(R)-(+)-Blebbistatin is an inactive enantiomer of the selective inhibitor of myosin II (±)-blebbistatin.
Active Enantiomer and Racemate also available.
Technical Data for (R)-(+)-Blebbistatin
| M. Wt | 292.34 |
| Formula | C18H16N2O2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1177356-70-5 |
| PubChem ID | 6604910 |
| InChI Key | LZAXPYOBKSJSEX-SFHVURJKSA-N |
| Smiles | O=C2[C@]3(O)C(N(C4=CC=CC=C4)CC3)=NC1=CC=C(C)C=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (R)-(+)-Blebbistatin
References for (R)-(+)-Blebbistatin
References are publications that support the biological activity of the product.
Limouze et al (2004) Specificity of blebbistatin, an inhibitor of myosin II. J.Muscle Res.Cell Motil. 25 337 PMID: 15548862
Straight et al (2003) Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor. Science 299 1743 PMID: 12637748
Straight et al (2002) Dissecting cytokinesis with small molecules. Amer.Soc.Cell Biol.Abstr. 2515
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Keywords: (R)-(+)-Blebbistatin, (R)-(+)-Blebbistatin supplier, Selective, inhibitors, inhibits, myosin, II, ATPase, (R)-(+)-Blebbistatin, Myosin, 1853, Tocris Bioscience
3 Citations for (R)-(+)-Blebbistatin
Citations are publications that use Tocris products. Selected citations for (R)-(+)-Blebbistatin include:
Maître et al (2016) Asymmetric division of contractile domains couples cell positioning and fate specification. Nature 536 344 PMID: 27487217
Bzymek et al (2016) Real-time two- and three-dimensional imaging of monocyte motility and navigation on planar surfaces and in collagen matrices: roles of Rho. Sci Rep 6 25016 PMID: 27122054
Nyholm et al (2009) A novel genetic mechanism regulates dorsolateral hinge-point formation during zebrafish cranial neurulation. J Cell Sci 122 2137 PMID: 19470582
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