S-Trityl-L-cysteine

Pricing Availability   Qty
说明: Potent, selective inhibitor of mitotic kinesin Eg5
别名: NSC 83265
化学名: S-(Triphenylmethyl)-L-cysteine
说明书
引用文献 (6)
评论 (1)
文献 (1)

生物活性 for S-Trityl-L-cysteine

S-Trityl-L-cysteine is a potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC50 of 700 nM. Displays antitumor activity.

技术数据 for S-Trityl-L-cysteine

分子量 363.47
公式 C22H21NO2S
储存 Store at +4°C
CAS Number 2799-07-7
PubChem ID 7271795
InChI Key DLMYFMLKORXJPO-HXUWFJFHSA-N
Smiles N[C@@H](C(O)=O)CSC(C2=CC=CC=C2)(C3=CC=CC=C3)C1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for S-Trityl-L-cysteine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 18.17 50

制备储备液 for S-Trityl-L-cysteine

以下数据基于产品分子量 363.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.5 mL 27.51 mL 55.03 mL
2.5 mM 1.1 mL 5.5 mL 11.01 mL
5 mM 0.55 mL 2.75 mL 5.5 mL
25 mM 0.11 mL 0.55 mL 1.1 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for S-Trityl-L-cysteine

参考文献 for S-Trityl-L-cysteine

参考文献是支持产品生物活性的出版物。

DeBonis et al (2004) In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumour activities. Mol.Cancer Ther. 3 1079 PMID: 15367702

Brier et al (2004) Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of mitotic kinesin Eg5. Biochemistry 43 13072 PMID: 15476401


If you know of a relevant reference for S-Trityl-L-cysteine, please let us know.

按产品操作查看相关产品

查看全部 Kinesin Inhibitors

关键词: S-Trityl-L-cysteine, S-Trityl-L-cysteine supplier, Potent, selective, inhibitors, inhibits, mitotic, kinesin, Eg5, Mitotic, Kinesin, Mitosis, NSC83265, NSC, 83265, 2191, Tocris Bioscience

6 篇 S-Trityl-L-cysteine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 S-Trityl-L-cysteine 的部分引用包括:

Müllers et al (2014) Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase. PLoS Genet 13 2733 PMID: 25486360

Hégarat et al (2014) PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit. J Pharmacol Exp Ther 10 e1004004 PMID: 24391510

Hengeveld (2017) Inner centromere localization of the CPC maintains centromere cohesion and allows mitoticcheckpoint silencing. Nat Commun 8 15542 PMID: 28561035

Cilibrasi et al (2019) A Ploidy Increase Promotes Sensitivity of Glioma Stem Cells to Aurora Kinases Inhibition. J Oncol 2019 9014045 PMID: 31531022

Hindriksen et al (2017) Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells. PLoS One 12 e0179514 PMID: 28640891

Ferreira et al (2018) Dissecting the role of the tubulin code in mitosis. Methods Cell Biol 144 33 PMID: 29804676


您是否知道使用了 Tocris S-Trityl-L-cysteine 的优秀论文? 请告知我们.

S-Trityl-L-cysteine 的评论

平均评分: 4 (Based on 1 Review.)

5 星
0%
4 星
100%
3 星
0%
2 星
0%
1 星
0%

Have you used S-Trityl-L-cysteine?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


STLC block cells at mitotic entry.
By Valeria Marotta on 10/07/2020
种属: Human
细胞系/组织: U2OS

I used the product to synchronise the cells at mitotic entry.

review image

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。


Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets