Salubrinal

Cat. No. 2347 11 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective inhibitor of eIF2α dephosphorylation

化学名： 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide

纯度： ≥99% (HPLC)

引用文献 (11)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Salubrinal

Salubrinal is a cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC₅₀ ~ 15 μM).

化合物库 for Salubrinal

Salubrinal is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Salubrinal

分子量	479.81
公式	C₂₁H₁₇N₄OSCl₃
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	405060-95-9
PubChem ID	5717801
InChI Key	LCOIAYJMPKXARU-VAWYXSNFSA-N
Smiles	S=C(NC(NC(/C=C/C3=CC=CC=C3)=O)C(Cl)(Cl)Cl)NC1=C2C(C=CC=N2)=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Salubrinal

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	47.98	100

制备储备液 for Salubrinal

以下数据基于产品分子量 479.81。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.08 mL	10.42 mL	20.84 mL
5 mM	0.42 mL	2.08 mL	4.17 mL
10 mM	0.21 mL	1.04 mL	2.08 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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产品说明书 for Salubrinal

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Salubrinal

参考文献是支持产品生物活性的出版物。

Boyce et al (2005) A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress. Science 307 935 PMID: 15705855

Long et al (2005) Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. Bioorg.Med.Chem.Lett. 15 3849 PMID: 16002288

If you know of a relevant reference for Salubrinal, please let us know.

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