Saquinavir mesylate

Cat. No. 4418 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： HIV protease inhibitor

别名： Ro 31-8959

化学名： (2S)-N1-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]butanediamide methanesulfonate

纯度： ≥99% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Saquinavir mesylate

Saquinavir mesylate is an inhibitor of human immunodeficiency virus (HIV) protease (K_i values are <0.1 and 0.12 nM for HIV-2 and HIV-1 protease respectively). Exhibits high antiviral activity and low cytotoxicity. In silico docking models predict potential as an inhibitor of SARS-CoV-2 3CL^pro.

化合物库 for Saquinavir mesylate

Saquinavir mesylate is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Saquinavir mesylate

分子量	766.95
公式	C₃₈H₅₀N₆O₅.CH₄O₃S
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	149845-06-7
PubChem ID	60934
InChI Key	IRHXGOXEBNJUSN-YOXDLBRISA-N
Smiles	O=C(N[C@@H](CC(N)=O)C(N[C@@H](CC4=CC=CC=C4)[C@H](O)CN3C[C@](CCCC5)([H])[C@]5([H])C[C@H]3[C@@](NC(C)(C)C)=O)=O)C2=NC1=CC=CC=C1C=C2.CS(=O)(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Saquinavir mesylate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	38.35	50

制备储备液 for Saquinavir mesylate

以下数据基于产品分子量 766.95。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	2.61 mL	13.04 mL	26.08 mL
2.5 mM	0.52 mL	2.61 mL	5.22 mL
5 mM	0.26 mL	1.3 mL	2.61 mL
25 mM	0.05 mL	0.26 mL	0.52 mL

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产品说明书 for Saquinavir mesylate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Saquinavir mesylate

参考文献是支持产品生物活性的出版物。

Krausslich et al (1992) Specific inhibitor of human immunodeficiency virus proteinase prevents the cytotoxic effects of a single-chain proteinase dimer and restores particle formation. J.Virol. 66 567 PMID: 1727499

Tucker et al (1992) A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity. J.Med.Chem. 35 2525 PMID: 1635054

Kaldor et al (1995) Isophthalic acid derivatives: amino acid surrogates for the inhibition of HIV-1 protease. Bioorg.Med.Chem.Lett. 5 721

Roberts et al (1990) Rational design of peptide-based HIV proteinase inhibitors. Science 248 358 PMID: 2183354

If you know of a relevant reference for Saquinavir mesylate, please let us know.

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1 篇 Saquinavir mesylate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Saquinavir mesylate 的部分引用包括：

Lan et al (2014) Provirus activation plus CD59 blockage triggers antibody-dependent complement-mediated lysis of latently HIV-1-infected cells. J Immunol 193 3577 PMID: 25149467

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