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Submit ReviewSB 505124
说明： Selective inhibitor of TGF-βRI, ALK4 and ALK7
化学名： 2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine
纯度： ≥98% (HPLC)
生物活性 for SB 505124
SB 505124 is a selective inhibitor of transforming growth factor-β type I receptor (ALK5), ALK4 and ALK7 (IC50 values are 47 and 129 nM for ALK5 and ALK4 respectively). Selectively inhibits signaling from TGF-β and activin; does not inhibit other ALK family members. Promotes adenine base editor activity in vivo and in vitro at 10 μM.
化合物库 for SB 505124
SB 505124 is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。
技术数据 for SB 505124
| 分子量 | 335.4 |
| 公式 | C20H21N3O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 694433-59-5 |
| PubChem ID | 9858940 |
| InChI Key | WGZOTBUYUFBEPZ-UHFFFAOYSA-N |
| Smiles | CC(C)(C)C1=NC(C2=CC(OCO4)=C4C=C2)=C(C3=NC(C)=CC=C3)N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SB 505124
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 33.54 | 100 | |
| 2eq. HCl | 33.54 | 100 |
制备储备液 for SB 505124
以下数据基于产品分子量 335.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.98 mL | 14.91 mL | 29.82 mL |
| 5 mM | 0.6 mL | 2.98 mL | 5.96 mL |
| 10 mM | 0.3 mL | 1.49 mL | 2.98 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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产品说明书 for SB 505124
参考文献 for SB 505124
参考文献是支持产品生物活性的出版物。
Byfield et al (2004) SB-505124 is a selective inhibitor of transforming growth factor-β type I receptors ALK4, ALK5, and ALK7. Mol.Pharmacol. 65 744 PMID: 14978253
Hu et al (2005) Reactive oxygen species production via NADPH oxidase mediates TGF-β-induced cytoskeletal alterations in endothelial cells. Am.J.Physiol.Renal Physiol. 289 F816 PMID: 16159901
Noma et al (2008) The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis. Gastroenterology 134 1981 PMID: 18439605
Yang et al (2022) Small-molecule activators specific to adenine base editors through blocking the canonical TGF-β pathway. Nucleic Acids Res. 50 9632 PMID: 36043443
If you know of a relevant reference for SB 505124, please let us know.
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关键词: SB 505124, SB 505124 supplier, SB505124, tgfβ, tgfbeta, tgfb, tgfbrI, tgfbetarI, tgfβrI, receptors, transforming, growth, factors, alk5, alk4, alk7, inhibitors, inhibits, ABE, adenine, base, editing, editor, TGF-beta, Receptors, BMP, and, Other, Activin, ALK, 3263, Tocris Bioscience
5 篇 SB 505124 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SB 505124 的部分引用包括：
Zhu et al (2016) Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis. Oncogene 35 5388 PMID: 27109105
Boxtel et al (2015) A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain. Dev Cell 35 175 PMID: 26506307
Ramel and Hill (2013) The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands. Dev Biol 378 170 PMID: 23499658
Yang et al (2017) Establishment of mouse expanded potential stem cells. Nature 550 393 PMID: 29019987
Asghar et al (2017) Potential role of indoleamine 2,3-dioxygenase in primary biliary cirrhosis. Oncol Lett 14 5497 PMID: 29113177
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.
Pathways for SB 505124
