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Submit ReviewSC 144 hydrochloride
说明： gp130 inhibitor; blocks cytokine-triggered gp130 signaling
化学名： 2-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl) 2-pyrazinecarboxylic acid hydrazide hydrochloride
纯度： ≥98% (HPLC)
生物活性 for SC 144 hydrochloride
SC 144 hydrochloride is an inhibitor of gp130 (IC50 = 0.72 μM); blocks cytokine-triggered gp130 signaling. SC 144 hydrochloride induces gp130 phosphorylation and down regulates gp130 glycosylation; also abrogates STAT3 phosphorylation, nuclear translocation and inhibits the expression of downstream target genes. SC 144 hydrochloride delays tumor growth in a mouse xenograft model of human ovarian cancer. Orally active.
化合物库 for SC 144 hydrochloride
SC 144 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for SC 144 hydrochloride
| 分子量 | 358.76 |
| 公式 | C16H11FN6O.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 917497-70-2 |
| PubChem ID | 66921431 |
| InChI Key | LKFGGXYXFIICED-UHFFFAOYSA-N |
| Smiles | O=C(C4=CN=CC=N4)NNC1=NC(C=C(F)C=C3)=C3N2C1=CC=C2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SC 144 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 32.23 | 100 |
制备储备液 for SC 144 hydrochloride
以下数据基于产品分子量 358.76。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.79 mL | 13.94 mL | 27.87 mL |
| 5 mM | 0.56 mL | 2.79 mL | 5.57 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.79 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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产品说明书 for SC 144 hydrochloride
参考文献 for SC 144 hydrochloride
参考文献是支持产品生物活性的出版物。
Xu et al (2013) Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. Mol.Cancer Ther. 12 937 PMID: 23536726
If you know of a relevant reference for SC 144 hydrochloride, please let us know.
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关键词: SC 144 hydrochloride, SC 144 hydrochloride supplier, SC144, hydrochloride, GP130, inhibitors, inhibits, blocks, cytokine, triggered, gp130, signaling, signalling, Stat3, nuclear, translocation, ovarian, cancer, Cytokines, 4963, Tocris Bioscience
7 篇 SC 144 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SC 144 hydrochloride 的部分引用包括：
Anurag et al (2018) Exogenous melatonin protects small-for-size liver grafts by promoting monocyte infiltration and releases interleukin-6. J Pineal Res 65 e12486 PMID: 29505662
Praachi et al (2022) Chronic hM4Di-DREADD-Mediated Chemogenetic Inhibition of Forebrain Excitatory Neurons in Postnatal or Juvenile Life Does Not Alter Adult Mood-Related Behavior. Eneuro 9 PMID: 35115382
Richard et al (2022) Cerebellar modulation of memory encoding in the periaqueductal grey and fear behaviour. Elife 11 PMID: 35287795
Jop et al (2022) A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression. Development 149 PMID: 35993866
Jennifer et al (2019) Sensory perception drives food avoidance through excitatory basal forebrain circuits. Elife 8 PMID: 31074744
Theo et al (2019) Vitronectin from brain pericytes promotes adult forebrain neurogenesis by stimulating CNTF. Exp Neurol 312 20-32 PMID: 30408465
Juan et al (2019) Method for Stimulation of Hippocampal Neurogenesis by Transient Microneedle Insertion. Methods Mol Biol 1919 227-235 PMID: 30656634
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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