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Submit ReviewSCH 28080
Discontinued Product
1690 has been discontinued.
View all H<sup>+</sup>,K<sup>+</sup>-ATPase products.
说明： H+,K+-ATPase inhibitor
化学名： 2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile
纯度： ≥99% (HPLC)
生物活性 for SCH 28080
SCH 28080 is a potent inhibitor of H+,K+-ATPase (IC50 = 20 nM); binds to the K+ recognition site and is competitive with respect to K+. Inhibits gastric acid secretion in vitro and in vivo.
技术数据 for SCH 28080
| 分子量 | 277.33 |
| 公式 | C17H15N3O |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 76081-98-6 |
| PubChem ID | 108137 |
| InChI Key | PYKJFEPAUKAXNN-UHFFFAOYSA-N |
| Smiles | CC1=C(CC#N)N2C=CC=C(OCC3=CC=CC=C3)C2=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SCH 28080
参考文献 for SCH 28080
参考文献是支持产品生物活性的出版物。
Long et al (1983) Gastric antisecretory and cytoprotective activities of SCH 28080. J.Pharmacol.Exp.Ther. 226 114 PMID: 6864535
Scott et al (1987) Studies on the mechanism of action of the gastric microsomal (H+K+)-ATPase inhibitors SCH 32651 and SCH 28080. Biochem.Pharmacol. 36 97 PMID: 3026407
Vagin et al (2002) SCH 28080, a K+-competitive inhibitor of the gastric H,K-ATPase, binds near the M5-6 luminal loop, preventing K+ access to the ion binding domain. Biochemistry 41 12755 PMID: 12379118
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关键词: SCH 28080, SCH 28080 supplier, H+K+-ATPase, inhibitors, inhibits, P-Type, ATPase, Ion, Transporters, Pumps, hydrogen, potassium-ATPase, SCH28080, H+,K+-ATPase, 1690, Tocris Bioscience
1 篇 SCH 28080 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SCH 28080 的部分引用包括：
Lynch et al (2010) Heterogeneity of H-K-ATPase-mediated acid secretion along the mouse collecting duct. Am J Physiol Renal Physiol 298 F408 PMID: 19923411
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