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SCH 28080

Cat. No. 1690 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： H+,K+-ATPase inhibitor
化学名： 2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyridine-3-acetonitrile
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SCH 28080

SCH 28080 is a potent inhibitor of H+,K+-ATPase (IC50 = 20 nM); binds to the K+ recognition site and is competitive with respect to K+. Inhibits gastric acid secretion in vitro and in vivo.

技术数据 for SCH 28080

分子量 277.33
公式 C17H15N3O
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 76081-98-6
PubChem ID 108137
InChI Key PYKJFEPAUKAXNN-UHFFFAOYSA-N
Smiles CC1=C(CC#N)N2C=CC=C(OCC3=CC=CC=C3)C2=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SCH 28080

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 2.77 10
DMSO 6.93 25

制备储备液 for SCH 28080

以下数据基于产品分子量 277.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.25 mM 14.42 mL 72.12 mL 144.23 mL
1.25 mM 2.88 mL 14.42 mL 28.85 mL
2.5 mM 1.44 mL 7.21 mL 14.42 mL
12.5 mM 0.29 mL 1.44 mL 2.88 mL

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产品说明书 for SCH 28080

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for SCH 28080

参考文献是支持产品生物活性的出版物。

Long et al (1983) Gastric antisecretory and cytoprotective activities of SCH 28080. J.Pharmacol.Exp.Ther. 226 114 PMID: 6864535

Scott et al (1987) Studies on the mechanism of action of the gastric microsomal (H+K+)-ATPase inhibitors SCH 32651 and SCH 28080. Biochem.Pharmacol. 36 97 PMID: 3026407

Vagin et al (2002) SCH 28080, a K+-competitive inhibitor of the gastric H,K-ATPase, binds near the M5-6 luminal loop, preventing K+ access to the ion binding domain. Biochemistry 41 12755 PMID: 12379118

If you know of a relevant reference for SCH 28080, please let us know.

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关键词: SCH 28080, SCH 28080 supplier, H+K+-ATPase, inhibitors, inhibits, P-Type, ATPase, Ion, Transporters, Pumps, hydrogen, potassium-ATPase, SCH28080, H+,K+-ATPase, 1690, Tocris Bioscience

1 篇 SCH 28080 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SCH 28080 的部分引用包括：

Lynch et al (2010) Heterogeneity of H-K-ATPase-mediated acid secretion along the mouse collecting duct. Am J Physiol Renal Physiol 298 F408 PMID: 19923411

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