SD 2590 hydrochloride

Cat. No. 4775 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent MMP inhibitor

别名： SC 78080

化学名： N-Hydroxy-1-(2-methoxyethyl)-4-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]-4-piperidinecarboxamide hydrochloride

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SD 2590 hydrochloride

SD 2590 hydrochloride is a potent MMP inhibitor (IC₅₀ values are <0.1, <0.1, 0.18, 1.7, 13 and 28.7 nM for MMP-2, -13, -9, -8, -14 and -3 respectively). Exhibits 100,000-fold selectivity for MMP-2 and -13 over MMP-1. Reduces left ventricular dilation in a myocardial infarction rat model. Orally bioavailable.

许可信息

Sold for research purposes under agreement from Pfizer Inc

化合物库 for SD 2590 hydrochloride

SD 2590 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SD 2590 hydrochloride

分子量	554.96
公式	C₂₂H₂₅F₃N₂O₇S.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	226395-93-3
PubChem ID	9893894
InChI Key	HJJOIVGDTLHVTK-UHFFFAOYSA-N
Smiles	O=S(C1(C(NO)=O)CCN(CCOC)CC1)(C2=CC=C(OC3=CC=C(OC(F)(F)F)C=C3)C=C2)=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SD 2590 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	55.5	100
	DMSO	55.5	100

制备储备液 for SD 2590 hydrochloride

以下数据基于产品分子量 554.96。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.8 mL	9.01 mL	18.02 mL
5 mM	0.36 mL	1.8 mL	3.6 mL
10 mM	0.18 mL	0.9 mL	1.8 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for SD 2590 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SD 2590 hydrochloride

参考文献是支持产品生物活性的出版物。

Becker et al (2010) Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease. J.Med.Chem. 53 6653 PMID: 20726512

If you know of a relevant reference for SD 2590 hydrochloride, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Matrix Metalloprotease Inhibitors

关键词: SD 2590 hydrochloride, SD 2590 hydrochloride supplier, SD2590, hydrochloride, SC78080, potent, MMP, MMP2, MMP13, MMP9, MMP8, MMP14, MMP3, MT1, SC, 78080, Matrix, Metalloprotease, 4775, Tocris Bioscience

篇 SD 2590 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 SD 2590 hydrochloride 的引用文献。您是否知道使用了 Tocris SD 2590 hydrochloride 的优秀论文？请告知我们.