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Submit ReviewSDZ 205-557 hydrochloride
说明： 5-HT3 and 5-HT4 antagonist
化学名： 4-Amino-5-chloro-2-methoxybenzoic acid 2-(diethylamino)ethyl ester hydrochloride
纯度： ≥99% (HPLC)
生物活性 for SDZ 205-557 hydrochloride
SDZ 205-557 hydrochloride is a 5-HT3/5-HT4 receptor antagonist.
技术数据 for SDZ 205-557 hydrochloride
| 分子量 | 337.25 |
| 公式 | C14H21ClN2O3.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1197334-02-3 |
| PubChem ID | 11957705 |
| InChI Key | JOWUQCJWCRNVMQ-UHFFFAOYSA-N |
| Smiles | Cl.CCN(CC)CCOC(=O)C1=CC(Cl)=C(N)C=C1OC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SDZ 205-557 hydrochloride
参考文献 for SDZ 205-557 hydrochloride
参考文献是支持产品生物活性的出版物。
Eglen et al (1993) The action of SDZ 205,557 at 5-hydroxytryptamine (5-HT3 and 5-HT4) receptors. Br.J.Pharmacol. 108 376 PMID: 8448587
McMahon and Cunningham (1999) Antagonism of 5-hydroxytryptamine(4) receptors attenuates hyperactivity induced by cocaine: putative role for 5-hydroxytryptamine(4) receptors in the nucleus accumbens shell. J.Pharmacol.Exp.Ther. 291 300 PMID: 10490917
Buchheit et al (1992) SDZ 205-557, a selective, surmountable antagonist for 5-HT4 receptors in the isolated guinea pig ileum. Naunyn-Schmied.Arch.Pharmacol. 345 387
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.