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Selinexor

Cat. No. 7760 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective exportin 1 (XPO1/CRM1) inhibitor
化学名： (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Selinexor

Selinexor is an inhibitor of the exportin 1 (XPO1/CRM1) nuclear exporter. Shows selectivity for TNBC over ER-positive breast cancer cell lines (IC50 values are 11-550 nM and >1000 nM, respectively), and reduces growth of xenografts. Inhibits growth of thyroid cancer cell lines (IC50 = 150-500 nM), potentiates the anti-tumor effects of Olaparib (Cat. No. 7579) in ovarian cancer and breast cancer. Also a potent inhibitor of SARS-CoV-2 replication in vitro (EC50 = 10 nM) and downregulates the production of pro-inflammatory cytokines including TNF-α and IL-6.

技术数据 for Selinexor

分子量 443.31
公式 C17H11F6N7O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1393477-72-9
PubChem ID 71481097
InChI Key DEVSOMFAQLZNKR-RJRFIUFISA-N
Smiles O=C(NNC1=NC=CN=C1)/C=C\N(C=N2)N=C2C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Selinexor

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 44.33 100
ethanol 22.17 50

制备储备液 for Selinexor

以下数据基于产品分子量 443.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.28 mL 22.56 mL
5 mM 0.45 mL 2.26 mL 4.51 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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参考文献 for Selinexor

参考文献是支持产品生物活性的出版物。

Arango et al (2017) Selinexor (KPT-330) demonstrates anti-tumor efficacy in preclinical models of triple-negative breast cancer. Breast Cancer Res. 19 93 PMID: 28810913

Marijon et al (2021) Selinexor, a selective inhibitor of nuclear export, enhances the anti-tumor activity of olaparib in triple negative breast cancer regardless of BRCA1 mutation status. Oncotarget. 12 1749 PMID: 34504648

Kashyap et al (2021) Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo. Antiviral Res. 192 105115 PMID: 34157321

If you know of a relevant reference for Selinexor, please let us know.

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关键词: Selinexor, Selinexor supplier, selective, inhibitors, exportin, nuclear, exporter, XPO1, CRM1, triple, negative, breast, cancer, thyroid, SARS-CoV-2, cytokines, DNA,, RNA, and, Protein, Synthesis, Coronavirus, 7760, Tocris Bioscience

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