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Submit ReviewSemax
Discontinued Product
7712 has been discontinued.
说明： Reduces Aβ aggregation and fibrillogenesis; neuroprotective and neurotrophic peptide
纯度： ≥95% (HPLC)
生物活性 for Semax
Semax is a synthetic heptapeptide analog of adrenocorticotropic hormone (ACTH) (4-10). It increases hippocampal BDNF and TrkB expression and levels in vivo. Semax regulates cortical nitric oxide (NO) and lipid peroxidation and is neuroprotective in a rat model of global ischemia. Semax sequesters copper ions and interacts directly with Aβ:Cu2+ oligomers leading to reduced amyloid β protein (Aβ) aggregation and fibrillogenesis. Semax increases viability of d-SH-SY5Y cells pre-incubated with Aβ1-42 oligomers.
技术数据 for Semax
| 分子量 | 813.93 |
| 公式 | C37H51N9O10S |
| 序列 | MEHFPGP |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 80714-61-0 |
| PubChem ID | 9811102 |
| InChI Key | AFEHBIGDWIGTEH-AQRCPPRCSA-N |
| Smiles | O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(NCC(N4[C@@H](CCC4)C(O)=O)=O)=O)=O)=O)=O)[C@H](CCSC)N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Semax
参考文献 for Semax
参考文献是支持产品生物活性的出版物。
Bashkatova (2001) Novel synthetic analogue of ACTH 4-10 (Semax) but not glycine prevents the enhanced nitric oxide generation in cerebral cortex of rats with incomplete global ischemia. Brain Res. 894 145 PMID: 11245825
Dolotov et al (2006) Semax, an analog of ACTH(4–10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res. 1117 54 PMID: 16996037
Sciacca et al (2022) Semax, a synthetic regulatory peptide, affects copper-induced Abeta aggregation and amyloid formation in artificial membrane models. ACS Chem.Neurosci. 13 486 PMID: 35080861
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关键词: Semax, Semax supplier, peptides, analogs, adrenocorticotropic, hormone, hippocampal, BDNF, trkB, neuroprotective, global, ischemia, amyloid, beta, Aβ, ABeta, aggregation, inhibits, fibrillogenesis, Alzheimers, Amyloid, Beta, Peptides, Other, RTKs, 7712, Tocris Bioscience
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Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.