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SF 11

Cat. No. 3898 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： NPY Y2 receptor antagonist
化学名： N-(4-Ethoxyphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SF 11

SF 11 is an NPY Y2 antagonist (IC50 = 199 nM). Displays no affinity for Y1 receptor at concentrations up to 35 μM. Causes significant lethality in mice. Displays antidepressant effects in rats. Brain penetrant.

化合物库 for SF 11

SF 11 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SF 11

分子量 446.6
公式 C27H30N2O2S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 443292-81-7
PubChem ID 2936384
InChI Key PMEQBGAGFZDWQX-UHFFFAOYSA-N
Smiles S=C(N2CCC(C(C4=CC=CC=C4)(O)C3=CC=CC=C3)CC2)NC1=CC=C(OCC)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SF 11

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 44.66 100
ethanol 22.33 50

制备储备液 for SF 11

以下数据基于产品分子量 446.6。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.2 mL 22.39 mL
5 mM 0.45 mL 2.24 mL 4.48 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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Dilution Calculator

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参考文献 for SF 11

参考文献是支持产品生物活性的出版物。

Brothers et al (2010) Selective and brain penetrant neuropeptide Y Y2 receptor antagonists discovered by whole-cell high-throughput screening. Mol.Pharmacol. 77 46 PMID: 19837904

Domin et al (2019) Characterization of the brain penetrant neuropeptide Y Y2 receptor antagonist SF-11. ACS Chem.Neurosci. 10 3454 PMID: 31267743

If you know of a relevant reference for SF 11, please let us know.

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关键词: SF 11, SF 11 supplier, neuropeptide, Y, NPY, Y2, antagonists, SF11, neuropeptides, Receptors, 3898, Tocris Bioscience

1 篇 SF 11 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SF 11 的部分引用包括：

Domin et al (2019) Characterization of the brain penetrant neuropeptide Y Y2 receptor antagonist SF-11. ACS Chem Neurosci 10 3454 PMID: 31267743

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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