Sivelestat sodium salt

Cat. No. 3535 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective leukocyte elastase inhibitor

别名： ONO-5046

化学名： N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine sodium salt

纯度： ≥98% (HPLC)

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Sivelestat sodium salt

Sivelestat sodium salt is a selective leukocyte elastase inhibitor (IC₅₀ = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-κB activation and LTB₄-induced neutrophil transmigration in vitro. Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo.

化合物库 for Sivelestat sodium salt

Sivelestat sodium salt is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Sivelestat sodium salt

分子量	456.44
公式	C₂₀H₂₁N₂NaO₇S
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	150374-95-1
PubChem ID	23664980
InChI Key	ZAIFANJZUGNYCK-UHFFFAOYSA-M
Smiles	[Na+].CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC1=CC=CC=C1C(=O)NCC([O-])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Sivelestat sodium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	22.82	50

制备储备液 for Sivelestat sodium salt

以下数据基于产品分子量 456.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	4.38 mL	21.91 mL	43.82 mL
2.5 mM	0.88 mL	4.38 mL	8.76 mL
5 mM	0.44 mL	2.19 mL	4.38 mL
25 mM	0.09 mL	0.44 mL	0.88 mL

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产品说明书 for Sivelestat sodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Sivelestat sodium salt

参考文献是支持产品生物活性的出版物。

Kawabata et al (1991) ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem.Biophys.Res.Commun. 177 814 PMID: 2049103

Young et al (2007) Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice. Br.J.Pharmacol. 151 628 PMID: 17471175

Hagiwara et al (2009) Neutrophil elastase inhibitor (sivelestat) reduces the levels of inflammatory mediators by inhibiting NF-κB. Inflamm.Res. 58 198 PMID: 19169649

Iwamoto et al (2009) Protective effect of sivelestat sodium hydrate (ONO-5046) on ischemic spinal cord injury. Interact.Cardiovasc.Thorac.Surg. 8 606 PMID: 19289399

If you know of a relevant reference for Sivelestat sodium salt, please let us know.

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