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SJ 3149

Cat. No. 8141 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective CK1α molecular glue Degrader
化学名： 3-(5-(Benzo[d]isoxazol-3-ylamino)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SJ 3149

SJ 3149 is a potent and selective CK1α molecular glue Degrader (DC50 = 3.7 nM; Dmax 95% in MOLM-13 cells). SJ 3149 induced near-complete degradation of the CK1α protein (DC50 = 6 nM at 4 hours). Potently inhibits the viability of MOLM-13 cells (IC50 = 13 nM). SJ 3149 displays a broad antiproliferative activity profile on a panel of acute leukemia and solid tumor cell lines. In vivo, SJ 3149 degrades CK1α protein levels in NSG mice transplanted with MOLM-13 cells. SJ 3149 shows 76% orally bioavailability.

许可信息

Sold under license from St. Jude Children's Research Hospital.

技术数据 for SJ 3149

分子量 376.37
公式 C20H16N4O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 3026986-17-1
PubChem ID 168511381
InChI Key AJUZTJBGJWQZFW-UHFFFAOYSA-N
Smiles O=C1NC(C(CC1)N2C(C3=CC=C(NC4=NOC5=C4C=CC=C5)C=C3C2)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SJ 3149

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 37.64 100

制备储备液 for SJ 3149

以下数据基于产品分子量 376.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.66 mL 13.28 mL 26.57 mL
5 mM 0.53 mL 2.66 mL 5.31 mL
10 mM 0.27 mL 1.33 mL 2.66 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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参考文献 for SJ 3149

参考文献是支持产品生物活性的出版物。

Nishiguchi et al (2024) Selective CK1a degraders exert antiproliferative activity against a broad range of human cancer cell lines. Nat.Commun. 15 482 PMID: 38228616

If you know of a relevant reference for SJ 3149, please let us know.

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关键词: SJ 3149, SJ 3149 supplier, SJ3149, molecular, glue, degrader, degraders, degrades, CK1, alpha, potent, selective, orally, bioavailable, MOLM13, viability, in, vivo, Molecular, Glues, Casein, Kinase, 1, 8141, Tocris Bioscience

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TPD and Induced Proximity Research Product Guide

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