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SJ 6986

Cat. No. 7720 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Molecular glue; induces degradation of GSPT1/2
化学名： N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SJ 6986

SJ 6986 is a potent and selective GSPT1/2 molecular glue Degrader (DC50 = 2.1 nM). The Degrader exhibits antiproliferative effects in human medulloblastoma and leukemia cell lines. (EC50 values are 0.4 nM, 1.5 nM, 336 nM, 726 nM and 3583 nM in MHH-CALL-4, MV4-11, MB004, MB002 and HD-MB03 cell lines, respectively). In vivo, SJ 6986 is stable in mouse (t1/2 = 4.7 h). This product is orally bioavailable.

许可信息

Sold under license from St. Jude Children's Research Hospital.

技术数据 for SJ 6986

分子量 497.4
公式 C20H14F3N3O7S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2765625-93-0
PubChem ID 155925914
InChI Key RKAFYSIKAVFVPS-UHFFFAOYSA-N
Smiles O=S(C1=CC=CC=C1OC(F)(F)F)(NC2=CC(C(N3C4C(NC(CC4)=O)=O)=O)=C(C=C2)C3=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SJ 6986

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 49.74 100

制备储备液 for SJ 6986

以下数据基于产品分子量 497.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.05 mL 20.1 mL
5 mM 0.4 mL 2.01 mL 4.02 mL
10 mM 0.2 mL 1.01 mL 2.01 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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参考文献 for SJ 6986

参考文献是支持产品生物活性的出版物。

Nishiguchi et al (2021) Identification of potent, selective, and orally bioavailable small- molecule GSPT1/2 degraders from a focused library of cereblon modulators. J.Med.Chem. 64 7296 PMID: 34042448

If you know of a relevant reference for SJ 6986, please let us know.

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关键词: SJ 6986, SJ 6986 supplier, SJ6986, GSPT1/2, molecular, glue, degraders, degrades, apoptosis, ubiquitination, orally, bioavailable, potent, selective, Molecular, Glues, 7720, Tocris Bioscience

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

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