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Submit ReviewSR 142948
说明： Highly potent NTS receptor antagonist
化学名： 2-[[[5-(2,6-Dimethoxyphenyl)-1-[4-[[[3-(dimethylamino)propyl]methylamino]carbonyl]-2-(1-methylethyl)phenyl]-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylic acid
纯度： ≥97% (HPLC)
生物活性 for SR 142948
SR 142948 is a potent non-peptide neurotensin (NT) receptor antagonist that binds with high affinity (IC50 = 0.32 - 3.96 nM; Ki < 10 nM). Attenuates amphetamine-induced hyperactivity and is orally active in vivo.
化合物库 for SR 142948
SR 142948 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for SR 142948
| 分子量 | 685.86 |
| 公式 | C39H51N5O6 |
| 储存 | Store at +4°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 184162-64-9 |
| PubChem ID | 5311451 |
| InChI Key | LWULHXVBLMWCHO-UHFFFAOYSA-N |
| Smiles | COC1=CC=CC(OC)=C1C1=CC(=NN1C1=C(C=C(C=C1)C(=O)N(C)CCCN(C)C)C(C)C)C(=O)NC1(C2CC3CC(C2)CC1C3)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SR 142948
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 51.44 | 75 | |
| water | 17.15 | 25 |
制备储备液 for SR 142948
以下数据基于产品分子量 685.86。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 1.94 mL | 9.72 mL | 19.44 mL |
| 3.75 mM | 0.39 mL | 1.94 mL | 3.89 mL |
| 7.5 mM | 0.19 mL | 0.97 mL | 1.94 mL |
| 37.5 mM | 0.04 mL | 0.19 mL | 0.39 mL |
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产品说明书 for SR 142948
参考文献 for SR 142948
参考文献是支持产品生物活性的出版物。
Gully et al (1997) Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist. J.Pharmacol.Exp.Ther. 280 802 PMID: 9023294
Quere et al (1998) X-ray structural characterization of SR 142948, a novel potent synthetic neurotensin receptor antagonist. Bioorg.Med.Chem.Lett. 8 653 PMID: 9871577
Marie-Claire et al (2008) Effects of the selective neurotensin antagonist SR 142948A on 3,4-methylenedioxymethamphetamine-induced behaviours in mice. Neuropharmacology 54 1107 PMID: 18410947
If you know of a relevant reference for SR 142948, please let us know.
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关键词: SR 142948, SR 142948 supplier, potent, NT, receptor, antagonists, Receptors, Neurotensin, SR142948, 2309, Tocris Bioscience
4 篇 SR 142948 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SR 142948 的部分引用包括：
Rouibi et al (2016) Ventral Midbrain NTS1 Receptors Mediate Conditioned Reward Induced by the Neurotensin Analog, D-Tyr[11]neurotensin. J Cereb Blood Flow Metab 9 470 PMID: 26733785
Yin et al (2008) Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling. Neuropharmacology 54 79 PMID: 17675102
Piccart et al (2015) Neurotensin Induces Presynaptic Depression of D2 DA Autoreceptor-Mediated Neurotransmission in Midbrain DArgic Neurons. J Neurosci 35 11144 PMID: 26245975
Olszewski-Hamilton and Hamilton (2011) Dependence of Relative Expression of NTR1 and EGFR on Cell Density and Extracellular pH in Human Pancreatic Cancer Cell Lines. Cancers (Basel) 3 182 PMID: 24212612
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