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Submit ReviewSSM 3 trifluoroacetate is a potent furin inhibitor (EC50 = 54 nM). Blocks furin-dependent cell surface processing of anthrax protective antigen-83 in vitro.
SSM 3 trifluoroacetate is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
分子量 | 952.66 |
公式 | C22H32N12O2.4CF3CO2H |
储存 | Store at -20°C |
纯度 | ≥98% (HPLC) |
CAS Number | 2320930-10-5 |
PubChem ID | 121513857 |
InChI Key | JYRRXGHBFAELIV-YAOLEPIASA-N |
Smiles | NC(N[C@H]1C[C@@H](NC(N)=N)[C@H](OC3=CC=C(NC(N)=N)C=C3)C[C@@H]1OC2=CC=C(NC(N)=N)C=C2)=N.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
water | 49.66 | 100 | |
DMSO | 49.66 | 100 |
以下数据基于产品分子量 952.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.05 mL | 5.25 mL | 10.5 mL |
5 mM | 0.21 mL | 1.05 mL | 2.1 mL |
10 mM | 0.1 mL | 0.52 mL | 1.05 mL |
50 mM | 0.02 mL | 0.1 mL | 0.21 mL |
参考文献是支持产品生物活性的出版物。
Remacle (2010) Selective and potent furin inhibitors protect cells from anthrax without significant toxicity. Int.J.Biochem.Cell Biol. 42 987 PMID: 20197107
If you know of a relevant reference for SSM 3 trifluoroacetate, please let us know.
关键词: SSM 3 trifluoroacetate, SSM 3 trifluoroacetate supplier, SSM3, SSM, 3, trifluoroacetate, furin, inhibitors, inhibits, SSM-3, 922732-52-3, Furin, 5253, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 SSM 3 trifluoroacetate 的部分引用包括:
Cheng et al (2020) Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects. Cell Rep. 33 PMID: 33007239
Rui et al (2021) Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets. J Clin Invest 131 PMID: 34128839
Hervouet et al (2022) An Arginine-Rich Motif in the ORF2 capsid protein regulates the hepatitis E virus lifecycle and interactions with the host cell. PLoS Pathog. 18 e1010798 PMID: 36007070
Dicenta et al (2024) The subtilisin-like protease furin regulates hemin-induced CD63 surface expression on platelets. Biochem.Biophys.Res.Commun. 701 149629 PMID: 38330730
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