SSM 3 trifluoroacetate

Pricing Availability   Qty
说明: Potent furin inhibitor
化学名: rel-N,N''-[[(1R,3S,4S,6R)-4,6-Bis[(aminoiminomethyl)amino]-1,3-cyclohexanedyil]bis(oxy-4,1-phenylene)]bisguanidine tetratrifluoroacetate salt
纯度: ≥98% (HPLC)
说明书
引用文献 (4)
评论

生物活性 for SSM 3 trifluoroacetate

SSM 3 trifluoroacetate is a potent furin inhibitor (EC50 = 54 nM). Blocks furin-dependent cell surface processing of anthrax protective antigen-83 in vitro.

化合物库 for SSM 3 trifluoroacetate

SSM 3 trifluoroacetate is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for SSM 3 trifluoroacetate

分子量 952.66
公式 C22H32N12O2.4CF3CO2H
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2320930-10-5
PubChem ID 121513857
InChI Key JYRRXGHBFAELIV-YAOLEPIASA-N
Smiles NC(N[C@H]1C[C@@H](NC(N)=N)[C@H](OC3=CC=C(NC(N)=N)C=C3)C[C@@H]1OC2=CC=C(NC(N)=N)C=C2)=N.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SSM 3 trifluoroacetate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 49.66 100
DMSO 49.66 100

制备储备液 for SSM 3 trifluoroacetate

以下数据基于产品分子量 952.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.05 mL 5.25 mL 10.5 mL
5 mM 0.21 mL 1.05 mL 2.1 mL
10 mM 0.1 mL 0.52 mL 1.05 mL
50 mM 0.02 mL 0.1 mL 0.21 mL

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产品说明书 for SSM 3 trifluoroacetate

分析证书/产品说明书
选择另一批次:

参考文献 for SSM 3 trifluoroacetate

参考文献是支持产品生物活性的出版物。

Remacle (2010) Selective and potent furin inhibitors protect cells from anthrax without significant toxicity. Int.J.Biochem.Cell Biol. 42 987 PMID: 20197107


If you know of a relevant reference for SSM 3 trifluoroacetate, please let us know.

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查看全部 Furin Inhibitors

关键词: SSM 3 trifluoroacetate, SSM 3 trifluoroacetate supplier, SSM3, SSM, 3, trifluoroacetate, furin, inhibitors, inhibits, SSM-3, 922732-52-3, Furin, 5253, Tocris Bioscience

4 篇 SSM 3 trifluoroacetate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SSM 3 trifluoroacetate 的部分引用包括:

Dicenta et al (2024) The subtilisin-like protease furin regulates hemin-induced CD63 surface expression on platelets. Biochem.Biophys.Res.Commun. 701 149629 PMID: 38330730

Cheng et al (2020) Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects. Cell Rep. 33 PMID: 33007239

Rui et al (2021) Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets. J Clin Invest 131 PMID: 34128839

Hervouet et al (2022) An Arginine-Rich Motif in the ORF2 capsid protein regulates the hepatitis E virus lifecycle and interactions with the host cell. PLoS Pathog. 18 e1010798 PMID: 36007070


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