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Stattic

Cat. No. 2798 18 篇引用文献 2 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective STAT3 inhibitor
化学名： 6-Nitrobenzo[b]thiophene 1,1-dioxide
纯度： ≥98% (HPLC)
说明书
引用文献 (18)
评论 (2)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Stattic

Stattic is a small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.

技术数据 for Stattic

分子量 211.19
公式 C8H5NO4S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 19983-44-9
PubChem ID 2779853
InChI Key ZRRGOUHITGRLBA-UHFFFAOYSA-N
Smiles O=S2(C1=CC([N+]([O-])=O)=CC=C1C=C2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Stattic

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 10.56 50

制备储备液 for Stattic

以下数据基于产品分子量 211.19。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 9.47 mL 47.35 mL 94.7 mL
2.5 mM 1.89 mL 9.47 mL 18.94 mL
5 mM 0.95 mL 4.74 mL 9.47 mL
25 mM 0.19 mL 0.95 mL 1.89 mL

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产品说明书 for Stattic

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Stattic

参考文献是支持产品生物活性的出版物。

Schust et al (2006) Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem.Biol. 13 1235 PMID: 17114005

If you know of a relevant reference for Stattic, please let us know.

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关键词: Stattic, Stattic supplier, Selective, STAT3, inhibitors, inhibits, STAT, Transcription, Factors, Signal, Transducers, activators, Cytokine, NF-κB, NF-kappaB, Signaling, Signalling, 2798, Tocris Bioscience

18 篇 Stattic 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Stattic 的部分引用包括：

Petes et al (2018) Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes. Front Immunol 9 256 PMID: 29497424

Visavadiya (2016) Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3. Cell Communication and Signaling 14 32 PMID: 27978828

Conner et al (2014) Repressing notch signaling and expressing TNFα are sufficient to mimic retinal regeneration by inducing Müller glial proliferation to generate committed progenitor cells. J Neurosci 34 14403 PMID: 25339752

Okada et al (2015) STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cells. PLoS One 93 461 PMID: 25582338

Fan et al (2018) Modulation of nuclear factor-kappa B activation by the endoplasmic reticulum stress sensor PERK to mediate estrogen-induced apoptosis in breast cancer cells. Cell Death Discov 4 15 PMID: 29531812

Banerjee et al (2017) Reduced FAK-STAT3 signaling contributes to ER stress-induced mitochondrial dysfunction and death in endothelial cells. Cell Signal 36 154 PMID: 28495589

Natarajan et al (2014) STAT3 modulation to enhance motor neuron differentiation in human neural stem cells. Cancer Res 9 e100405 PMID: 24945434

Shravah et al (2014) PropF. mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKT. Nat Commun 3 e29554 PMID: 25105067

Price et al (2013) Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. JAKSTAT 73 3441 PMID: 23729642

Dong et al (2017) Interleukin-22 participates in the inflammatory process of vitiligo. Oncotarget 8 109161 PMID: 29312598

Keasey et al (2013) Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Commun Signal 11 35 PMID: 23693126

Haynes et al (2013) Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration. Nat Commun 4 2312 PMID: 23942241

Beales and Ogunwobi (2009) Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation. J Mol Endocrinol 42 305 PMID: 19153190

Ko et al (2016) STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9. Yonsei Med J 57 761 PMID: 26996579

Peda et al (2016) Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease. Dis Model Mech 9 1051 PMID: 27491076

Liu et al (2013) Stat3 inhibition attenuates mechanical allodynia through transcriptional regulation of chemokine expression in spinal astrocytes. PLoS One 8 e75804 PMID: 24098399

Katz et al (2012) Targeting of Rac GTPases blocks the spread of intact human breast cancer. Oncotarget 3 608 PMID: 22689141

Hodge et al (2012) IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia. Blood 120 3774 PMID: 22976953

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Stattic 的评论

平均评分: 4 (基于 2 条评论。)

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Mitochondrial bioenergetics measurements by reagent screen.
By Anonymous on 03/15/2020
分析类型： In Vitro
种属： Mouse
细胞系/组织： mouse brain endothelioma cell line

10 μM

PMID: 27978828
review image
Static inhibition of STAT3 pathway.
By Mark Stauffer on 01/04/2018
分析类型： In Vitro
种属： Human
细胞系/组织： U87

Used to potentially inhibit signal transduction of the stat3 pathway in U87 cells, and was compared with other potential inhibitors in their effectivness of signal transduction when treating cells with pathway activators. It was assessed using RT-PCR for markers of pathway activation to see what inhibitor was most effective.

Pathways for Stattic

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.