Stoppin 2

Discontinued Product

4851 has been discontinued.

View all Ubiquitin E3 Ligases products.
说明: Competitive p53-MDM2/MDMX interaction inhibitor
说明书
引用文献
评论
文献 (3)

生物活性 for Stoppin 2

Competitive inhibitor of the p53-MDM2/MDMX interaction (Kd = 493 nM for MDM2). Kills tumor cells in a p53-dependent manner.

许可信息

Sold under license from the University of Maryland, Baltimore

技术数据 for Stoppin 2

分子量 3313.03
公式 C141H223N47O32S7
序列 CYSFDCLWKCLAMGFRRGKCRRRKCKC

(Modifications: Disulfide bridges: 1-20, 6-25,10-27)

储存 Store at -20°C
CAS Number 1069134-09-3
Smiles [H]N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC4=C1C=CC=C4)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Stoppin 2

参考文献是支持产品生物活性的出版物。

Li et al (2008) Turning a scorpion toxin into an antitumor miniprotein. J.Am.Chem.Soc. 130 13546 PMID: 18798622

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关键词: Stoppin 2, Stoppin 2 supplier, Stoppin-2, p53-MDM2, interaction, inhibitors, inhibits, antitumor, antitumour, MDM2, MDMX, p53-MDMX, Ligases, Transcription, Factors, Ubiquitin, E3, p53, 4851, Tocris Bioscience

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