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FITC-CHIPOpt

Cat. No. 8045 Submit a Review Datasheet / COA / SDS
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Description: Fluorescent CHIP/STUB1 E3 ligase inhibitor
Purity: ≥95% (HPLC)
Datasheet
Citations
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Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for FITC-CHIPOpt

FITC-CHIPOpt is a fluorescent CHIP/STUB1 E3 ligase inhibitor. It binds to CHIP and can be used in CHIP fluorescent polarization (FP) binding assays. Enables CHIP FP binding assays to be developed for new inhibitor or CHIP ligand synthesis. FITC-CHIPOpt is the fluorescent version of CHIPOp (Cat. No. 8044).

Technical Data for FITC-CHIPOpt

M. Wt 1218.35
Formula C64H67N9O14S
Sequence XLWWPD

(Modifications: X-1 = FTIC-6-aminohexanoic acid
Storage Store at -20°C
Purity ≥95% (HPLC)
InChI Key WHLHAYSAZOFWTL-TVKYAJOTSA-N
Smiles O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N5[C@@H](CCC5)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)[C@H](CC(C)C)NC(CCCCCNC(NC(C=C6C(O)=O)=CC=C6C(C7=C8C=C(O)C=C7)=C(C=C9)C(O8)=CC9=O)=S)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FITC-CHIPOpt

Solubility Soluble to 1 mg/ml in PBS

References for FITC-CHIPOpt

References are publications that support the biological activity of the product.

Nadel et al (2023) The E3 ubiquitin ligase, CHIP/STUB1, inhibits aggregation of phosphorylated proteoforms of microtubule-associated protein tau (MAPT). J.Mol.Biol. 435 168026 PMID: 37330289

Ravalin et al (2019) Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases. Nat.Chem.Biol. 15 786 PMID: 31320752

If you know of a relevant reference for FITC-CHIPOpt, please let us know.

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Citations for FITC-CHIPOpt

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Literature in this Area

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