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T2AA

Cat. No. 4723 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4723 has been discontinued.

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说明： PCNA inhibitor
化学名： (βS)-β-Amino-4-(4-hydroxyphenoxy)-3,5-diiodobenzenpropanol
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论 (1)
文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for T2AA

T2AA is a proliferating cell nuclear antigen (PCNA) inhibitor; inhibits PCNA/PIP-box peptide interaction (IC50 ~1 μM). Causes DNA replication stress by stalling DNA replication forks. Inhibits PCNA interaction with DNA polymerase δ and arrests cell growth in S-phase. Suppresses cancer cell growth.

许可信息

Sold under license from St. Jude Childrens Research Hospital

技术数据 for T2AA

分子量 511.09
公式 C15H15I2NO3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1380782-27-3
PubChem ID 71185540
InChI Key NKOSKXJRVWVXRI-JTQLQIEISA-N
Smiles IC1=C(OC2=CC=C(O)C=C2)C(I)=CC(C[C@H](N)CO)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for T2AA

参考文献是支持产品生物活性的出版物。

Punchihewa et al (2012) Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J.Biol.Chem. 287 14289 PMID: 22383522

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关键词: T2AA, T2AA supplier, Proliferating, cell, nuclear, antigen, PCNA, inhibitors, inhibits, DNA, replication, forks, DNA,, RNA, and, Protein, Synthesis, Polymerase, 4723, Tocris Bioscience

1 篇 T2AA 的引用文献

引用文献是使用了 Tocris 产品的出版物。 T2AA 的部分引用包括：

Carl L et al (2020) Dynamic Assembly and Disassembly of the Human DNA Polymerase δ Holoenzyme on the Genome In Vivo. Cell Rep 30 1329-1341.e5 PMID: 32023453

T2AA 的评论

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T2AA completely kills melanoma cell line at micromolar concentrations.
By Anonymous on 02/07/2019
分析类型： In Vitro
种属： Human
细胞系/组织： SK-MEL-28

Used for killing assay for in vitro cell culture. Cells were cultured for 24 hours before the addition of the compound into the media at low micromolar concentrations (indicated by the arrow).

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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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