T4

Cat. No. 7054 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Modulator of alternative polyadenylation; inhibits rod photoreceptor gene expression via Nr2e3

化学名： 6,7-Dimethoxy-2-[((4-phenyl-3,6-dihydropyridin-1(2H)-yl)methyl)]quinazolin-4(3H)-one

纯度： ≥98% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for T4

T4 is a modulator of alternative polyadenylation (APA) (IC₅₀ values are 2.1 μM and 8.5 μM in U2OS and 293T cells, respectively). T4 promotes distal-to-proximal APA usage in multiple transcripts, using distinctive A-rich motifs through autoregulated PABPN1 signaling. T4 exhibits no inhibitory activity against a panel of 414 kinases. T4 prevents retinal degeneration in the Rho^P23H mouse model of retinitis pigmentosa. T4 inhibits rod photoreceptor gene expression via Nr2e3 in a luciferase-based assay (IC₅₀ = 0.07 μM).

技术数据 for T4

分子量	377.44
公式	C₂₂H₂₃N₃O₃
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	785708-33-0
PubChem ID	135415476
InChI Key	CKCSOMMBIPJYSG-UHFFFAOYSA-N
Smiles	COC1=C(OC)C=C2C(C(NC(CN3CCC(C4=CC=CC=C4)=CC3)=N2)=O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for T4

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	0.75	2

制备储备液 for T4

以下数据基于产品分子量 377.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.02 mM	132.47 mL	662.36 mL	1324.71 mL
0.1 mM	26.49 mL	132.47 mL	264.94 mL
0.2 mM	13.25 mL	66.24 mL	132.47 mL
1 mM	2.65 mL	13.25 mL	26.49 mL

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产品说明书 for T4

分析证书/产品说明书

化学品安全技术说明书

参考文献 for T4

参考文献是支持产品生物活性的出版物。

Nakamura et al (2017) Small molecule photoregulin3 prevents retinal degeneration in the Rho ^P23H mouse model of retinitis pigmentosa. ELife 6 PMID: 29148976

Araki et al (2018) Decoding transcriptome dynamics of genome-encoded polyadenylation and autoregulation with small-molecule modulators of alternative polyadenylation. Cell.Chem.Biol. 25 1470 PMID: 30293940

If you know of a relevant reference for T4, please let us know.

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关键词: T4, T4 supplier, T4, photoregulin3, alternative, polyadenylation, polyadenylators, polyadenylate, RNA, APA, modulators, modulates, DNA,, and, Protein, Synthesis, 7054, Tocris Bioscience

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T4