Talabostat mesylate

Cat. No. 3719 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent DPP IV inhibitor; activates NLRP1b inflammasome

别名： Val-boroPro,BXCL 701

化学名： B-[(2R)-1-[(2S)-2-Amino-3-methyl-1-oxobutyl]-2-pyrrolidinyl]boronic acid methanesulfonate

纯度： ≥98% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Talabostat mesylate

Talabostat mesylate is a potent DPP IV inhibitor (IC₅₀ values are <4, 4, 11, 310 and 560 nM at DPP4, DPP8, DPP9, DPP7 and FAP, respectively). Activates the inflammasome sensor protein NLRP1b and selectively triggers pyroptosis in monocytes and macrophages. Induces immune-mediated tumor regression in multiple mouse models of cancer. Orally bioavailable.

技术数据 for Talabostat mesylate

分子量	310.18
公式	C₉H₁₉BN₂O₃.CH₃SO₃H
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	150080-09-4
PubChem ID	11522448
InChI Key	OXYYOEIGQRXGPI-WSZWBAFRSA-N
Smiles	O=C([C@@H](N)C(C)C)N1CCC[C@H]1B(O)O.CS(O)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Talabostat mesylate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	31.02	100
	DMSO	15.51	50

制备储备液 for Talabostat mesylate

以下数据基于产品分子量 310.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.22 mL	16.12 mL	32.24 mL
5 mM	0.64 mL	3.22 mL	6.45 mL
10 mM	0.32 mL	1.61 mL	3.22 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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产品说明书 for Talabostat mesylate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Talabostat mesylate

参考文献是支持产品生物活性的出版物。

Okondo et al (2017) DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis. Nat.Chem.Biol. 13 46 PMID: 27820798

Okondo et al (2018) Inhibition of Dpp8/9 activates the Nlrp1b inflammasome. Cell Chem.Biol. 25 262 PMID: 29396289

If you know of a relevant reference for Talabostat mesylate, please let us know.

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关键词: Talabostat mesylate, Talabostat mesylate supplier, Potent, DPP, IV, inhibitors, inhibits, inflammasome, pyroptosis, Nlrp1b, BXCL701, DPP4, Val-boroPro, BXCL, 701, Dipeptidyl, Peptidase, (DPP-IV), Inflammasomes, 3719, Tocris Bioscience