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Talniflumate

Cat. No. 2510 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2510 has been discontinued.

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说明： CaCC blocker and Cl-/HCO3- exchange inhibitor
化学名： 2-[[3-(Trifluoromethyl)phenyl]amino]-1,3-dihydro-3-oxo-1-isobenzofuranyl 3-pyridinecarboxylic acid ester
纯度： ≥99% (HPLC)
说明书
引用文献
评论 (1)
文献 (1)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Talniflumate

Talniflumate is a calcium-activated chloride channel (CaCC) (hCLCA1/mCLCA3) blocker; reduces mucin synthesis and release in cell culture and animal models. Possesses anti-inflammatory actions via inhibition of cyclooxygenases and inhibits Cl-/HCO3- exchanger activity. Increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.

技术数据 for Talniflumate

分子量 414.34
公式 C21H13F3N2O4
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 66898-62-2
PubChem ID 48229
InChI Key ANMLJLFWUCQGKZ-UHFFFAOYSA-N
Smiles FC(F)(F)C1=CC(NC2=NC=CC=C2C(=O)OC2OC(=O)C3=CC=CC=C23)=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Talniflumate

参考文献是支持产品生物活性的出版物。

Walker et al (2006) Talniflumate increases survival in a cystic fibrosis mouse model of distal intestinal obstructuve syndrome. J.Pharmacol.Exp.Ther. 317 275 PMID: 16354791

Sanchez et al (1982) Action of a non-steroidal anti-inflammatory drug on gastric mucosa of rats. J.Appl.Toxicol. 2 42

Knight (2004) Talniflumate (Genaera). Curr.Opin.Invest.Drugs 5 557

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关键词: Talniflumate, Talniflumate supplier, Cyclooxygenase, inhibitors, inhibits, chloride, channels, blockers, Chloride, hCLCA1/mCLCA3, COX, Oxygenases, Oxidases, Cl-/HCO3-, exchangers, CaCC, calcium-activated, Ca2+-Activated, Channels, 2510, Tocris Bioscience

篇 Talniflumate 的引用文献

引用文献是使用了 Tocris 产品的出版物。

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Talniflumate 的评论

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Activity evaluation of Talniflumate carried out..
By Anonymous on 08/26/2019
种属： Human

Activity evaluation of Talniflumate carried out. Human pancreatic cancer cell line MIA PaCa and BxPC-3 were used.

Cells were were incubated with different concentrations of Talniflumate (50, 100, 150 and 200 mkM), gefitinib and the combination of talniflumate and gefitinib for 24h.

该领域的文献

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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Talniflumate

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.