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Submit ReviewTAPI 0
说明： ADAM-17 (TACE) and MMP inhibitor
别名： TNF-α processing inhibitor-0
化学名： N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-L-alaninamide
纯度： ≥95% (HPLC)
生物活性 for TAPI 0
TAPI 0 is an ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 (Cat. No. 2983) to inhibit Chlamydia trachomatis growth.
技术数据 for TAPI 0
| 分子量 | 456.54 |
| 公式 | C24H32N4O5 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 163958-73-4 |
| PubChem ID | 3035404 |
| InChI Key | CRCPLBFLOSEABN-VBSNWNEZSA-N |
| Smiles | ONC(C[C@@H](CC(C)C)C(N[C@@H](CC1=CC(C=CC=C2)=C2C=C1)C(N[C@@H](C)C(N)=O)=O)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for TAPI 0
| 溶解性 | Soluble to 10 mg/ml in DMSO |
产品说明书 for TAPI 0
参考文献 for TAPI 0
参考文献是支持产品生物活性的出版物。
Balakrishnan et al (2006) Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. J.Biol.Chem. 281 16691 PMID: 16565079
Rzeniewicz et al (2015) L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro. Proc.Natl.Acad.Sci.USA. 112 E1461 PMID: 25775539
If you know of a relevant reference for TAPI 0, please let us know.
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关键词: TAPI 0, TAPI 0 supplier, TAPI0, ADAM17, metalloproteases, MMPs, metalloproteinases, inhibits, inhibitors, adams, TNFa, TNFα, converting, enzyme, TACE, TNF-a, processing, inhibitor-0, ADAMs, Matrix, Metalloprotease, 5523, Tocris Bioscience
2 篇 TAPI 0 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TAPI 0 的部分引用包括：
Wulf et al (2021) Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells. Cells 10 PMID: 34831323
Mina J et al (2020) Systems-Level Properties of EGFR-RAS-ERK Signaling Amplify Local Signals to Generate Dynamic Gene Expression Heterogeneity. Cell Syst 11 161-175.e5 PMID: 32726596
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