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Targapremir 210

Cat. No. 6586 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6586 has been discontinued.

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说明： Inhibits formation of miR-210
化学名： N-(3-Azidopropyl)-4-[3-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1H-benzimidazol]-2'-yl]phenoxy]butanamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for Targapremir 210

Targapremir 210 inhibits formation of mature miR-210 (IC50 = 200 nM) by binding to Dicer binding site of the miR-210 hairpin precursor (Kd = 200 nM) and inhibits Dicer processing of the miRNA. Decreases levels of miR-210 and HIF-1α mRNA, and induces apoptosis in MDA-MB-231 cells cultured under hypoxic conditions. Reduces tumor expression of HIF-1α mRNA and miR-210, and tumor growth in a triple negative breast cancer mouse model.

技术数据 for Targapremir 210

分子量 592.71
公式 C32H36N10O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1049722-30-6
PubChem ID 44221088
InChI Key PAYVJEWMAWLKAP-UHFFFAOYSA-N
Smiles CN1CCN(C2=CC=C3N=C(C4=CC=C5N=C(C6=CC(OCCCC(NCCCN=[N+]=[N-])=O)=CC=C6)NC5=C4)NC3=C2)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Targapremir 210

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Targapremir 210

参考文献是支持产品生物活性的出版物。

Costales et al (2017) Small molecule inhibition of microRNA-210 reprograms an oncogenic hypoxic circuit. J.Am.Chem.Soc. 139 3446 PMID: 28240549

Childs-Disney et al (2012) Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive. ACS.Chem.Biol 7 856 PMID: 22332923

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关键词: Targapremir 210, Targapremir 210 supplier, micro, RNA, miRNA, inhibitors, inhibits, miR-210, triple, negative, breast, cancer, hypoxia, HIF1a, alpha, alfa, α, DNA,, and, Protein, Synthesis, 6586, Tocris Bioscience

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