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TC-E 5002

Cat. No. 5089 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective KDM2/7 inhibitor
化学名： N-(9-Cyclopropyl-1-oxononyl)-N-hydroxy-β-alanine
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TC-E 5002

TC-E 5002 is a selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). Inhibits growth of HeLa and KYSE-150 cancer cells in vitro.

化合物库 for TC-E 5002

TC-E 5002 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for TC-E 5002

分子量 285.38
公式 C15H27NO4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1453071-47-0
PubChem ID 71735843
InChI Key NEHSERYKENINRH-UHFFFAOYSA-N
Smiles O=C(N(CCC(O)=O)O)CCCCCCCCC1CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC-E 5002

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1eq. NaOH 28.54 100
DMSO 28.54 100

制备储备液 for TC-E 5002

以下数据基于产品分子量 285.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.5 mL 17.52 mL 35.04 mL
5 mM 0.7 mL 3.5 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.5 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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参考文献 for TC-E 5002

参考文献是支持产品生物活性的出版物。

Suzuki et al (2013) Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J.Med.Chem. 56 PMID: 23964788

If you know of a relevant reference for TC-E 5002, please let us know.

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关键词: TC-E 5002, TC-E 5002 supplier, TC-E5002, histone, demthylases, KDM2/7, KDM2A, KDM7A, KDM7B, subfamily, inhibitors, inhibits, Histone, Demethylases, 5089, Tocris Bioscience

1 篇 TC-E 5002 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TC-E 5002 的部分引用包括：

David E et al (2022) NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition. Mol Cell 82 2472-2489.e8 PMID: 35537449

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.