TC LPA5 4

Name: TC LPA5 4
Brand: Tocris Bioscience
SKU: 4708
Rating: 5 (1 reviews)

Cat. No. 4708 3 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： LPA₅ receptor antagonist

化学名： 5-(3-Chloro-4-cyclohexylphenyl)-1-(3-methoxyphenyl)-1H-pyrazole-3-carboxylic acid

纯度： ≥98% (HPLC)

说明书

引用文献 (3)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TC LPA5 4

TC LPA5 4 is an LPA₅ receptor antagonist (IC₅₀ = 0.8 μM in LPA₅-RH7777 cells). TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelets. Exhibits selectivity for LPA₅ against 80 other screened targets.

化合物库 for TC LPA5 4

TC LPA5 4 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TC LPA5 4

分子量	410.89
公式	C₂₃H₂₃ClN₂O₃
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1393814-38-4
PubChem ID	66552906
InChI Key	BNALUYKEGYUHQC-UHFFFAOYSA-N
Smiles	ClC(C=C(C3=CC(C(O)=O)=NN3C4=CC=CC(OC)=C4)C=C2)=C2C1CCCCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC LPA5 4

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	41.09	100
	ethanol	8.22	20

制备储备液 for TC LPA5 4

以下数据基于产品分子量 410.89。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.17 mL	24.34 mL
5 mM	0.49 mL	2.43 mL	4.87 mL
10 mM	0.24 mL	1.22 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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产品说明书 for TC LPA5 4

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TC LPA5 4

参考文献是支持产品生物活性的出版物。

Kozian et al (2012) Selective non-lipid modulator of LPA₅ activity in human platelets. Bioorg.Med.Chem.Lett. 22 5239 PMID: 22801643

If you know of a relevant reference for TC LPA5 4, please let us know.

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关键词: TC LPA5 4, TC LPA5 4 supplier, TCLPA54, LPA, LPA5, Lysophosphatidic, acid, receptors, platelets, aggregation, antagonists, Acid, Receptors, 4708, Tocris Bioscience

3 篇 TC LPA5 4 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TC LPA5 4 的部分引用包括：

Shuh et al (2022) Single-cell RNA sequencing identifies a migratory keratinocyte subpopulation expressing THBS1 in epidermal wound healing. iScience 25 104130 PMID: 35391830

Kittaka et al (2017) Lysophosphatidic acid-induced itch is mediated by signalling of LPA₅ receptor, phospholipase D and TRPA1/TRPV1. J Physiol 595 2681 PMID: 28176353

Plastira et al (2017) Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype. J Neuroinflammation 14 253 PMID: 29258556

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TC LPA5 4 的评论

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TC LPA5 4 in the inhibition of LPA induced proinflammatory phenotype in microglia.

By Joanna Plastira on 10/09/2018

分析类型： In Vitro

种属： Mouse

细胞系/组织： BV2 and primary microglia

TC LPA5 4 was used in order to study the role of LPAR5 in murine microglia. The inhibitor was used in many different experimental procedures (WB, IF, qPCR, flow cytometry, functional assays) and the results were consistent..Up to 10µM the inhibitor was well tolerated by the cells. Higher concentrations have not been tested (and were not necessary).

参考文献

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