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Submit ReviewTC NTR1 17
说明： Selective NTS1 partial agonist
别名： ML 301 analog
化学名： N-[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]-L-leucine
纯度： ≥99% (HPLC)
生物活性 for TC NTR1 17
TC NTR1 17 is a non-peptide neurotensin receptor 1 (NTS1) partial agonist (EC50 <15.6 nM and Emax = 63% of neurotensin response in Ca2+ mobilization assay). Exhibits over 50-fold selectivity for NTS1 over NTS2 and GPR35.
化合物库 for TC NTR1 17
TC NTR1 17 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for TC NTR1 17
| 分子量 | 522.98 |
| 公式 | C27H27ClN4O5 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1146757-96-1 |
| PubChem ID | 44157038 |
| InChI Key | ZQUSYVORYNBGLG-FQEVSTJZSA-N |
| Smiles | O=C(N[C@@H](CC(C)C)C(O)=O)C2=NN(C(C3=C(OC)C=CC=C3OC)=C2)C1=C(C=CC(Cl)=C4)C4=NC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for TC NTR1 17
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 52.3 | 100 | |
| 1eq. NaOH | 26.15 | 50 |
制备储备液 for TC NTR1 17
以下数据基于产品分子量 522.98。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.91 mL | 9.56 mL | 19.12 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.82 mL |
| 10 mM | 0.19 mL | 0.96 mL | 1.91 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
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产品说明书 for TC NTR1 17
参考文献 for TC NTR1 17
参考文献是支持产品生物活性的出版物。
Hershberger et al (2014) Imidazole-derived agonists for the neurotensin 1 receptor. Bioorg.Med.Chem.Lett. 24 262 PMID: 24332089
If you know of a relevant reference for TC NTR1 17, please let us know.
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关键词: TC NTR1 17, TC NTR1 17 supplier, TCNTR117, ML301, analogs, non-peptide, selective, neurotensin, receptors, NTS1, NTR1, partial, agonists, ML, 301, analog, Neurotensin, Receptors, 5087, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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