TCS PrP Inhibitor 13

Name: TCS PrP Inhibitor 13
Brand: Tocris Bioscience
SKU: 3238

Cat. No. 3238 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3238 has been discontinued.

View all Prion Protein products.

说明： Antiprion agent; inhibits PrP^Sc accumulation

化学名： 2,4-Dihydro-5-(4-nitrophenyl)-2-phenyl-3H-pyrazol-3-one

纯度： ≥98% (HPLC)

说明书

引用文献 (2)

通路 (1)

生物活性技术数据说明书参考文献

生物活性 for TCS PrP Inhibitor 13

TCS PrP Inhibitor 13 is an antiprion agent. Potently inhibits protease-resistant prion protein (PrP-res) accumulation in two types of prion-infected mouse neuroblastoma (N2a) cell lines (IC₅₀ = 3 nM). Also reduces PrP expression and decreases proliferation and survival in schwannoma cell lines.

技术数据 for TCS PrP Inhibitor 13

分子量	281.27
公式	C₁₅H₁₁N₃O₃
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	34320-83-7
PubChem ID	2750328
InChI Key	FDAVFKZPGQEGDX-UHFFFAOYSA-N
Smiles	O=C(C2)N(C3=CC=CC=C3)N=C2C1=CC=C([N+]([O-])=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for TCS PrP Inhibitor 13

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TCS PrP Inhibitor 13

参考文献是支持产品生物活性的出版物。

Kimata et al (2007) New series of antiprion compounds: pyrazolone derivatives have potent activity of inhibiting protease-resistant prion protein accumulation. J.Med.Chem. 50 5053 PMID: 17850126

Provenzano et al (2017) Cellular prion protein (PrPC) in the development of Merlin-deficient tumours. Oncogene. 36 6132 PMID: 28692055

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关键词: TCS PrP Inhibitor 13, TCS PrP Inhibitor 13 supplier, Antiprion, agent, potently, inhibits, inhibitors, PrP-res, accumulation, Prion, Protein, Neuronal, Metabolism, TCSPrP, Inhibitor13, 3238, Tocris Bioscience

2 篇 TCS PrP Inhibitor 13 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TCS PrP Inhibitor 13 的部分引用包括：

Safavifar et al (2019) Augmented cAMP Signaling by Co-Administration of Resveratrol and Curcumin: A Cellular Biosensor Kinetic Assessment. Iran J Public Health 48 1310 PMID: 31497553

Provenzano et al (2017) Cellular prion protein (PrPC) in the development of Merlin-deficient tumours. Oncogene. PMID: 28692055