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Submit ReviewTelaprevir
说明： Hepatitis C virus (HCV) protease NS3/4A inhibitor
别名： VX-950,LY-570310
化学名： (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide
纯度： ≥98% (HPLC)
生物活性 for Telaprevir
Telaprevir is a hepatitis C virus (HCV) protease NS3/4A inhibitor. Orally bioavailable. Inhibits HCV RNA replication in vitro (IC50 = 0.35 μM). Also used in Stabilizable Polypeptide Linkages (StaPLs) chemogenetic platform, for pharmacological regulation of protein expression/function. StaPL sequences can be engineered into target proteins rendering them functional only in the presence of Telaprevir.
Plasmid vectors for the transfection of cells with StaPLs are available from Addgene.
技术数据 for Telaprevir
| 分子量 | 679.85 |
| 公式 | C36H53N7O6 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 402957-28-2 |
| PubChem ID | 3010818 |
| InChI Key | BBAWEDCPNXPBQM-GDEBMMAJSA-N |
| Smiles | [H][C@@]12CCC[C@@]1([C@@H](C(N[C@H](C(C(NC3CC3)=O)=O)CCC)=O)N(C([C@H](C(C)(C)C)NC([C@H](C4CCCCC4)NC(C5=NC=CN=C5)=O)=O)=O)C2)[H] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Telaprevir
参考文献 for Telaprevir
参考文献是支持产品生物活性的出版物。
Jacobs et al (2018) StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins. Nat.Methods 15 523 PMID: 29967496
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关键词: Telaprevir, Telaprevir supplier, hepatitis, C, virus, HCV, NS3, NS4A, protease, inhibitors, inhibits, orally, bioavailable, StaPLs, stabilizable, polypeptide, linkages, VX-950, LY-570310, Other, Proteases, Hepatitis, Viruses, 6658, Tocris Bioscience
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