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(-)-Terreic acid

Cat. No. 1405 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1405 has been discontinued.

说明： Selective inhibitor of BTK
化学名： (1R,6S)-3-Hydroxy-4-methyl-7-oxabicyclo[4.1.0]hept-3-ene-2,5-dione
纯度： ≥99% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for (-)-Terreic acid

(-)-Terreic acid is a selective inhibitor of Bruton's tyrosine kinase (BTK). Inhibits the interaction between PKCbII and BTK (IC50 ~ 30 mM) and the catalytic activity of BTK but does not affect the activity of PKC. Has little effect on the activities of Lyn, Syk, PKA, casein kinase I, ERK1, ERK2 and p38 kinases.

技术数据 for (-)-Terreic acid

分子量 154.12
公式 C7H6O4
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 121-40-4
PubChem ID 91437
InChI Key ATFNSNUJZOYXFC-RQJHMYQMSA-N
Smiles CC1=C(O)C(=O)[C@@H]2O[C@@H]2C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for (-)-Terreic acid

分析证书/产品说明书
化学品安全技术说明书

参考文献 for (-)-Terreic acid

参考文献是支持产品生物活性的出版物。

Kawakami et al (1999) Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase. Proc.Natl.Acad.Sci.U.S.A. 96 2227 PMID: 10051623

Subramanian et al (1982) In vivo and in vitro studies on the binding nature of terreic acid with macromolecules such as protein and nucleic acids. Toxicol.Lett. 10 249 PMID: 7080093

Yamamoto et al (1980) Studies on terreic acid. Jpn.J.Antibiot. 33 320 PMID: 7190624

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关键词: Terreic acid, Terreic acid supplier, Selective, inhibitors, inhibits, BTK, Brutons, Tyrosine, Kinases, Kinase, (BTK), 1405, Tocris Bioscience

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