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Submit ReviewTiplaxtinin
说明： Plasminogen activator inhibitor-1 (PAI-1) inhibitor
别名： PAI 039,tiplasinin
化学名： α-Oxo-1-(phenylmethyl)-5-[4-(trifluoromethoxy)phenyl]-1H-indole-3-acetic acid
纯度： ≥98% (HPLC)
生物活性 for Tiplaxtinin
Tiplaxtinin is a plasminogen activator inhibitor-1 (PAI-1) inhibitor (IC50 = 2.7 μM). Induces vascular smooth muscle cell apoptosis in vitro and reduces carotid artery neointimal formation in a rat vascular injury model. Promotes thrombolysis in rat and dog models of acute arterial thrombosis. Orally available.
化合物库 for Tiplaxtinin
Tiplaxtinin is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for Tiplaxtinin
| 分子量 | 439.38 |
| 公式 | C24H16F3NO4 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 393105-53-8 |
| PubChem ID | 6450819 |
| InChI Key | ODXQFEWQSHNQNI-UHFFFAOYSA-N |
| Smiles | O=C(C(O)=O)C2=CN(CC3=CC=CC=C3)C1=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Tiplaxtinin
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 43.94 | 100 | |
| ethanol | 43.94 | 100 |
制备储备液 for Tiplaxtinin
以下数据基于产品分子量 439.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.28 mL | 11.38 mL | 22.76 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.55 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.28 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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产品说明书 for Tiplaxtinin
参考文献 for Tiplaxtinin
参考文献是支持产品生物活性的出版物。
Elokdah et al (2004) Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization. J.Med.Chem. 47 3491 PMID: 15214776
Simone et al (2015) A small molecule PAI-1 functional inhibitor attenuates neointimal hyperplasia and vascular smooth muscle cell survival by promoting PAI-1 cleavage. Cell.Signal. 27 923 PMID: 25617690
If you know of a relevant reference for Tiplaxtinin, please let us know.
关键词: Tiplaxtinin, Tiplaxtinin supplier, thrombolysis, thrombolytic, PAI-1, plasminogen, activator, inhibitors, inhibits, apoptosis, inducers, induces, orally, available, PAI039, PAI, 039, tiplasinin, Plasminogen, Activator, Inhibitor, 1, 5565, Tocris Bioscience
1 篇 Tiplaxtinin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Tiplaxtinin 的部分引用包括：
Zhang et al (2020) ACSL3-PAI-1 signaling axis mediates tumor-stroma cross-talk promoting pancreatic cancer progression. Sci Adv 6 PMID: 33127675
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