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Submit ReviewTocrifluor T1117
说明： Fluorescent cannabinoid ligand; fluorescent form of AM 251 (Cat. No. 1117)
化学名： N-(Piperidin-1-yl)-5-(4-(4-(3-(5-carboxamidotetramethylrhodaminyl)propyl))phenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
纯度： ≥95% (HPLC)
生物活性 for Tocrifluor T1117
Tocrifluor T1117 is a fluorescent form of AM 251. AM 251 conjugated with 5-carboxytetramethylrhodamine (5-TAMRA) that fluoresces at 543 nm excitation (590 nm emission). Displays GPR55 binding activity. Wavelengths are compatible with use as an acceptor dye in TR-FRET assays, together with the CoraFluor™ 1 (Cat. No. 7920) TR-FRET donor.
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Optical Data for Tocrifluor T1117
| λabs | 543 nm |
|---|---|
| λem | 590 nm |
| Application | Fluorescence Microscopy, Confocal Microscopy |
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技术数据 for Tocrifluor T1117
| 分子量 | 974.97 |
| 公式 | C56H53Cl2N7O5 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 1186195-59-4 |
| PubChem ID | 57369426 |
| InChI Key | RNAPRXIZPJDYPH-UHFFFAOYSA-N |
| Smiles | CN(C)C1=CC2=C(C=C1)C1(OC(=O)C3=C1C=CC(=C3)C(=O)NCCCC1=CC=C(C=C1)C1=CC=C(C=C1)C1=C(C)C(=NN1C1=CC=C(Cl)C=C1Cl)C(=O)NN1CCCCC1)C1=C(O2)C=C(C=C1)N(C)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Tocrifluor T1117
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 9.75 | 10 |
制备储备液 for Tocrifluor T1117
以下数据基于产品分子量 974.97。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 10.26 mL | 51.28 mL | 102.57 mL |
| 0.5 mM | 2.05 mL | 10.26 mL | 20.51 mL |
| 1 mM | 1.03 mL | 5.13 mL | 10.26 mL |
| 5 mM | 0.21 mL | 1.03 mL | 2.05 mL |
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产品说明书 for Tocrifluor T1117
参考文献 for Tocrifluor T1117
参考文献是支持产品生物活性的出版物。
Daly et al (2010) Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries. Br.J.Pharmacol. 159 787 PMID: 20136833
Daly et al (2008) Visualisation of vascular cannabinoid receptors and their potential interaction with α1-adrenergic receptors. Vascular and Smooth Muscle Phys.Soc. Symposium
Sylantyev et al (2013) Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses. Proc.Natl.Acad.Sci.U.S.A. 110 5193 PMID: 23472002
Bruno et al (2014) Beyond radio-displacement techniques for identification of CB1 ligands: the first application of a fluorescence-quenching assay. Sci.Rep. 4 3757 PMID: 24441508
If you know of a relevant reference for Tocrifluor T1117, please let us know.
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关键词: Tocrifluor T1117, Tocrifluor T1117 supplier, fluorescent, CB1, receptor, ligands, Fluorescent, Probes, cannabinoids, Receptors, cb1r, cb2r, TR-FRET, F, Receptor, GPR55, and, FP, Assay, Reagents, 2540, Tocris Bioscience
3 篇 Tocrifluor T1117 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Tocrifluor T1117 的部分引用包括：
Daly et al (2010) Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries. Br J Pharmacol 159 787 PMID: 20136833
Stornaiuolo et al (2015) Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments. Sci Rep 5 15453 PMID: 26482099
Tortoriello et al (2013) Targeted lipidomics in Drosophila melanogaster identifies novel 2-monoacylglycerols and N-acyl amides. PLoS One 8 e67865 PMID: 23874457
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Fluorescent Dyes and Probes Research Product Guide
This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:
- Fluorescent Dyes, including dyes for flow cytometry
- Fluorescent Probes and Stains, including our new MitoBrilliantTM mitochondria stains
- Tissue Clearing Kits and Reagents
- Aptamer-based RNA Imaging Reagents
- Fluorescent Probes for Imaging Bacteria
- TSA VividTM Fluorophore Kits
- TSA Reagents for Enhancing IHC, ICC & FISH Signals
