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Submit ReviewTokeOni
说明： NIR-emission luciferin analog; ideal for deep tissue applications; orally bioavailable and brain penetrant
别名： AkaLumine HCl
化学名： (4S)-2-[(1E,3E)-4-[4-(Dimethylamino)phenyl]-1,3-butadien-1-yl]-4,5-dihydro-4-thiazolecarboxylic acid hydrochloride
纯度： ≥90% (HPLC)
生物活性 for TokeOni
TokeOni is a near-infrared red (NIR)-emission luciferin analog. Peak luminescence at 677 nM. ~40-fold brighter than the luciferin-luciferase system in vitro, and 100-1000 times brighter in vivo. Allows non-invasive visualization of single cells deep inside freely moving animals. Ideal for deep tissue applications. Water soluble (<40 mM), orally bioavailable and brain penetrant.
This product is supplied as a hydrochloride salt, the stoichiometry of which is batch dependant. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.
Optical Data for TokeOni
| Emission Color | Near-IR |
|---|---|
| λem | 677 nm |
| Application | BLI, BTI, Deep Tissue Applications |
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
Spectral Viewer
技术数据 for TokeOni
| M. Wt | 302.39 (Free Base) |
| 公式 | C16H18N2O2S.xHCl |
| 储存 | Store at -20°C |
| 纯度 | ≥90% (HPLC) |
| PubChem ID | 124203055 |
| InChI Key | PZCNKVAGZCXXHX-SSRSOBHISA-N |
| Smiles | CN(C1=CC=C(C=C1)/C=C/C=C/C2=N[C@@H](C(O)=O)CS2)C.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for TokeOni
| 溶解性 | Soluble to 5 mg/ml in water with gentle warming and to 10 mg/ml in DMSO |
产品说明书 for TokeOni
参考文献 for TokeOni
参考文献是支持产品生物活性的出版物。
Kuchimaru et al (2016) A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging. Nat. Commun. 7 11856 PMID: 27297211
Nasu et al (2018) Unnaturally aglow with a bright inner light. Science 359 868 PMID: 29472468
Iwano et al (2018) Single-cell bioluminescence imaging of deep tissue in freely moving animals. Science 359 935 PMID: 29472486
If you know of a relevant reference for TokeOni, please let us know.
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1 篇 TokeOni 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TokeOni 的部分引用包括：
Vivien et al (2022) Firefly luciferase offers superior performance to AkaLuc for tracking the fate of administered cell therapies. Eur J Nucl Med Mol Imaging 49 796-808 PMID: 34313817
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Fluorescent Dyes and Probes Research Product Guide
This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:
- Fluorescent Dyes, including dyes for flow cytometry
- Fluorescent Probes and Stains, including our new MitoBrilliantTM mitochondria stains
- Tissue Clearing Kits and Reagents
- Aptamer-based RNA Imaging Reagents
- Fluorescent Probes for Imaging Bacteria
- TSA VividTM Fluorophore Kits
- TSA Reagents for Enhancing IHC, ICC & FISH Signals