Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTP 064
说明： Potent and selective PRMT 4 inhibitor
化学名： N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide
纯度： ≥98% (HPLC)
生物活性 for TP 064
TP 064 is a potent and selective PRMT4 inhibitor; inhibits methylation of H3 (1-25) and MED12 (IC50 values are <10 and 43 nM, respectively). Exhibits >100-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits proliferation of certain multiple myeloma cell lines, arresting cells in G1 phase. TP 064 can be used in vivo. TP 064 inhibits the monocyte/macrophage-driven inflammation in ex vivo.
To request the negative control for TP 064, please fill out the TP 064N request form on the SGC website..
许可信息
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TP 064 probe summary on the SGC website.
化合物库 for TP 064
TP 064 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。
技术数据 for TP 064
| 分子量 | 458.6 |
| 公式 | C28H34N4O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2080306-20-1 |
| PubChem ID | 122707126 |
| InChI Key | VUIITYLFSAXKIQ-UHFFFAOYSA-N |
| Smiles | O=C(N(C)CC1=CC(C2CCN(CCNC)CC2)=NC=C1)C3=CC=CC(OC4=CC=CC=C4)=C3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for TP 064
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| 1eq. HCl | 45.86 | 100 | |
| DMSO | 45.86 | 100 |
制备储备液 for TP 064
以下数据基于产品分子量 458.6。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.18 mL | 10.9 mL | 21.81 mL |
| 5 mM | 0.44 mL | 2.18 mL | 4.36 mL |
| 10 mM | 0.22 mL | 1.09 mL | 2.18 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for TP 064
参考文献 for TP 064
参考文献是支持产品生物活性的出版物。
Nakayama et al (2018) TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma. Oncotarget 9 18480 PMID: 29719619
Scheer et al (2019) A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat.Commun. 10 19 PMID: 30604761
Zhang et al (2021) PRMT4 inhibitor TP-064 inhibits the pro-inflammatory macrophage lipopolysaccharide response in vitro and ex vivo and induces peritonitis-associated neutrophilia in vivo. Biochim.Biophys.Acta Mol.Basis Dis. 1867 166212 PMID: 34311083
If you know of a relevant reference for TP 064, please let us know.
关键词: TP 064, TP 064 supplier, TP064, Potent, allosteric, inhibitors, inhibits, of, protein, arginine, methyltransferase, 4, PRMT4, methylation, Protein, Arginine, Methyltransferases, 6008, Tocris Bioscience
9 篇 TP 064 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TP 064 的部分引用包括：
Zhang et al (2021) PRMT4 inhibitor TP-064 inhibits the pro-inflammatory macrophage lipopolysaccharide response in vitro and ex vivo and induces peritonitis-associated neutrophilia in vivo. Biochim.Biophys.Acta Mol.Basis Dis. 1867 166212 PMID: 34311083
Yingze et al (2021) Endotoxin stabilizes protein arginine methyltransferase 4 (PRMT4) protein triggering death of lung epithelia. Cell Death Dis 12 828 PMID: 34480022
Mark T et al (2021) CARM1 regulates replication fork speed and stress response by stimulating PARP1. Mol Cell 81 784-800.e8 PMID: 33412112
Clemons et al (2022) Protein arginine methyltransferase 4 modulates nitric oxide synthase uncoupling and cerebral blood flow in Alzheimer's disease. J Cell Physiol 10 jcp.30858 PMID: 36036549
Yingze et al (2023) Protein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis. Thorax 78 383-393 PMID: 35354645
Lauren E et al (2022) Arginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair. Sci Adv 8 eadd8928 PMID: 36475791
Mark T et al (2022) Pan-methylarginine antibody generation using PEG linked GAR motifs as antigens. Methods 200 80-86 PMID: 34107353
Clemons et al (2022) Protein arginine methyltransferase 4 modulates nitric oxide synthase uncoupling and cerebral blood flow in Alzheimer's disease J Cell Physiol PMID: 36036549
Zhong et al (2018) CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer. Cell Rep 24 3207 PMID: 30232003
您是否知道使用了 Tocris TP 064 的优秀论文？ 请告知我们.
TP 064 的评论
目前没有该产品的评论。 Be the first to review TP 064 and earn rewards!
Have you used TP 064?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.